Rablet IT Capsule PR

Description

Rablet IT Capsule PR is a prescription medication marketed by Lupin Ltd. It combines two active ingredients: Rabeprazole (20 mg) and Itopride (150 mg), which work together to treat gastrointestinal conditions involving both acid reflux and impaired gastric motility.

Composition:

• Rabeprazole (20 mg) – A proton pump inhibitor (PPI) that reduces stomach acid production.
• Itopride (150 mg) – A prokinetic agent that helps improve gastrointestinal motility, reducing symptoms like bloating and nausea.

Mechanism of Action:

1. Rabeprazole (20 mg):
   • Rabeprazole works by inhibiting the proton pump (H+/K+ ATPase) in the stomach lining, which reduces the production of gastric acid. This helps in conditions like GERD and peptic ulcers, where excess acid can cause irritation, inflammation, and discomfort.
2. Itopride (150 mg):
   • Itopride is a dopamine antagonist that has a dual action: it acts as a prokinetic agent (increasing gastric motility) and also has an antiemetic (anti-nausea) effect. It helps to accelerate gastric emptying, improving digestion and reducing symptoms like bloating, fullness, and nausea. Itopride also inhibits acetylcholinesterase, which helps in enhancing the action of acetylcholine, a neurotransmitter that promotes gut motility.

Indications:

Rablet IT Capsule PR is used for conditions that involve both acid reflux and impaired motility of the stomach and intestines. The main indications include:

• Gastroesophageal Reflux Disease (GERD): To relieve symptoms like heartburn, acid regurgitation, and inflammation in the esophagus.
• Dyspepsia (Indigestion): Helps with symptoms such as bloating, discomfort, and nausea.
• Gastroparesis: A condition where the stomach empties more slowly than normal, causing symptoms like nausea, vomiting, and bloating.
• Functional dyspepsia: A condition of unclear origin that causes symptoms of indigestion, including fullness, discomfort, and early satiety (feeling full quickly).
• Peptic Ulcers: It helps in healing ulcers by reducing stomach acid and improving gastrointestinal motility, which may be slowed due to the ulcer.

Dosage:

The typical dose for Rablet IT Capsule PR is one capsule daily, taken before a meal (usually in the morning). The exact dosage and duration of treatment should be determined by a healthcare provider based on the specific condition and response to the treatment.

Side Effects:

Common side effects may include:

• Headache
• Nausea or vomiting
• Abdominal discomfort
• Diarrhea or constipation
• Flatulence (gas)
• Dry mouth or bitter taste

Less common but more serious side effects could include:

• Severe allergic reactions (e.g., rash, swelling, difficulty breathing)
• Liver dysfunction (rare but should be monitored)
• Extrapyramidal symptoms (e.g., tremors, rigidity) due to itopride
• QT prolongation (a heart rhythm abnormality), especially in those with a history of heart conditions or when used with certain other medications.

If any severe side effects occur, contact your healthcare provider immediately.

Precautions:

• Pregnancy and Breastfeeding:
  Rabeprazole should be used during pregnancy only if the potential benefit justifies the risk. Itopride should be avoided during pregnancy unless absolutely necessary. Both drugs pass into breast milk, so breastfeeding mothers should consult their healthcare provider before using this medication.
• Liver and Kidney Impairment:
  Caution is required in patients with liver or kidney disease. A dose adjustment may be necessary for those with moderate to severe liver impairment.
• Heart Conditions:
  Itopride, although rare, can cause extrapyramidal symptoms (movement disorders). People with a history of heart conditions, especially arrhythmias, should use this medication under medical supervision.
• Long-term Use:
  Prolonged use of PPIs like rabeprazole can increase the risk of gastrointestinal infections, bone fractures, and low magnesium levels. Long-term use requires monitoring by a healthcare provider.

Drug Interactions:

• Clopidogrel (blood thinner): Rabeprazole may reduce the effectiveness of clopidogrel, which could increase the risk of blood clots.
• Antacids or H2 blockers: These can reduce the effectiveness of rabeprazole by altering stomach pH.
• Methotrexate: Rabeprazole may increase methotrexate levels, increasing the risk of toxicity.
• Prokinetic drugs (e.g., metoclopramide): Caution should be used when combining with other prokinetic agents, as they may increase the risk of movement disorders.
• Dopamine antagonists: Combining itopride with other dopamine antagonists may increase the risk of extrapyramidal side effects.