Rablet IV Injection (Lupin)

Description

Rablet IV Injection is a prescription medication marketed by Lupin Ltd. It contains Rabeprazole (20 mg), a proton pump inhibitor (PPI), and is used primarily in the hospital setting for the treatment of acid-related gastrointestinal disorders.

Composition:

• Rabeprazole (20 mg) – The active ingredient. It is a proton pump inhibitor that works by reducing the production of stomach acid.

Mechanism of Action:

• Rabeprazole inhibits the proton pump (H+/K+ ATPase) in the stomach’s parietal cells, which is responsible for the final step in the production of gastric acid. By blocking this pump, Rabeprazole reduces the amount of gastric acid secreted into the stomach, helping to heal ulcers, reduce inflammation, and alleviate symptoms related to excess acid.

Indications:

Rablet IV Injection is used in the following situations:

• Severe GERD (Gastroesophageal Reflux Disease): To treat symptoms like heartburn, acid regurgitation, and inflammation in the esophagus.
• Peptic Ulcers: Helps promote healing of gastric or duodenal ulcers and is often used in combination with antibiotics in the treatment of H. pylori infections.
• Gastritis: Used to treat inflammation of the stomach lining caused by excess acid.
• Zollinger-Ellison Syndrome: A condition where tumors in the pancreas or duodenum cause excessive stomach acid production.
• Prophylaxis of stress ulcer: Often used in critically ill patients to prevent stress-related ulcers, particularly in intensive care settings.

Dosage:

The typical dose of Rablet IV Injection is 20 mg administered intravenously (IV). The dosing schedule and duration of therapy depend on the patient’s condition and their response to the medication. It is usually administered by a healthcare professional in a hospital or clinical setting.

• For GERD or peptic ulcers: The dose may be given once or twice daily, depending on the severity of the condition.
• For Zollinger-Ellison syndrome: The dose may be adjusted higher as needed to control acid production.

IV administration is generally used when oral administration is not feasible, such as in critically ill patients or those who cannot take medications orally.

Side Effects:

Common side effects of Rablet IV Injection may include:

• Headache
• Nausea or vomiting
• Diarrhea or constipation
• Abdominal discomfort
• Flatulence (gas)

Rare but more serious side effects:

• Severe allergic reactions (e.g., rash, swelling, difficulty breathing)
• Liver dysfunction (may require monitoring of liver enzymes)
• Low magnesium levels (which can cause muscle cramps, seizures, or abnormal heart rhythms)
• Kidney problems or acute interstitial nephritis (rare)
• Increased risk of infections like Clostridium difficile-associated diarrhea with prolonged use.

Precautions:

• Pregnancy and Breastfeeding: Rabeprazole should be used during pregnancy only if the potential benefit justifies the risk. Rabeprazole is excreted in breast milk, so caution is advised in breastfeeding women.
• Liver or Kidney Impairment: Rabeprazole is metabolized in the liver, and its clearance may be reduced in patients with liver impairment. For kidney issues, the medication should be used with caution.
• Long-term Use: Prolonged use of PPIs like rabeprazole has been associated with risks, such as bone fractures, gastrointestinal infections, and low magnesium levels. Long-term therapy should be carefully monitored by healthcare professionals.
• Allergic Reactions: If you develop signs of a serious allergic reaction (e.g., difficulty breathing, swelling of the face or throat), seek emergency medical attention immediately.

Drug Interactions:

• Clopidogrel (blood thinner): Rabeprazole may reduce the effectiveness of clopidogrel, potentially increasing the risk of blood clots.
• Methotrexate: Rabeprazole can elevate methotrexate levels, increasing the risk of toxicity.
• Antacids or H2 blockers: These can reduce the effectiveness of rabeprazole by altering stomach pH.
• Warfarin (blood thinner): Caution is required when using rabeprazole with warfarin, as it may increase the anticoagulant effect and the risk of bleeding.

Administration:

• Rablet IV Injection is typically administered by intravenous infusion or bolus injection by a trained healthcare provider in a clinical setting.
• It is important to follow proper dilution and administration guidelines to avoid complications or adverse reactions.