Rablet L Capsule SR

Rablet L Capsule SR is a prescription medication marketed by Lupin Ltd. It contains a combination of two active ingredients: Levosulpiride (75 mg) and Rabeprazole (20 mg). This combination is typically used to treat gastrointestinal disorders that involve both acid reflux and motility issues.

Composition:

• Levosulpiride (75 mg): A prokinetic agent that promotes gastrointestinal motility and reduces symptoms like nausea and bloating. It also acts as a dopamine antagonist, which helps improve stomach motility.
• Rabeprazole (20 mg): A proton pump inhibitor (PPI) that reduces stomach acid production by blocking the proton pump in the stomach lining.

Mechanism of Action:

1. Levosulpiride:
   • Levosulpiride acts as a prokinetic (enhancing motility) agent by blocking dopamine receptors in the gastrointestinal tract. It helps in accelerating gastric emptying and improving the movement of food through the stomach and intestines. This can be particularly helpful for conditions where digestion is delayed, such as functional dyspepsia or gastroparesis.
2. Rabeprazole:
   • Rabeprazole works by inhibiting the H+/K+ ATPase proton pump in the stomach’s parietal cells, which reduces the secretion of gastric acid. It helps in treating acid-related conditions like GERD (Gastroesophageal Reflux Disease) and peptic ulcers by lowering stomach acid levels.

Indications:

Rablet L Capsule SR is used to treat conditions that involve both acid reflux and delayed gastric motility. The common indications include:

• Gastroesophageal Reflux Disease (GERD): To reduce symptoms like heartburn, acid regurgitation, and inflammation of the esophagus.
• Functional Dyspepsia (Indigestion): To relieve symptoms such as bloating, early satiety (feeling full quickly), nausea, and upper abdominal discomfort.
• Gastroparesis: A condition in which the stomach empties slowly, causing symptoms like nausea, vomiting, and bloating.
• Peptic Ulcers: It helps promote healing of ulcers by reducing gastric acid and improving motility, which may aid in digestion and absorption.
• Dyspepsia: For overall improvement of digestion in patients with functional or non-ulcer dyspepsia.

Dosage:

The usual dose for Rablet L Capsule SR is one capsule daily, preferably in the morning before meals. The exact dosage and duration depend on the condition being treated and the patient’s response to the therapy.

• For GERD or functional dyspepsia: Typically, one capsule once daily for 4-8 weeks.
• For gastroparesis: The dose may be adjusted according to the severity of symptoms.

Important: Always follow the dosage and treatment duration as prescribed by your healthcare provider.

Side Effects:

Common side effects of Rablet L Capsule SR may include:

• Headache
• Nausea or vomiting
• Diarrhea or constipation
• Abdominal pain or discomfort
• Dizziness or lightheadedness

Less common but more serious side effects could include:

• Severe allergic reactions (e.g., rash, swelling, difficulty breathing)
• Liver dysfunction (elevated liver enzymes, jaundice)
• Extrapyramidal symptoms (e.g., tremors, muscle stiffness, especially with levosulpiride)
• QT prolongation (heart rhythm abnormalities) – Rare, but may require monitoring in patients with heart disease.

If you experience any serious side effects, contact your healthcare provider immediately.

Precautions:

• Pregnancy and Breastfeeding:
  • Levosulpiride is generally not recommended during pregnancy unless necessary, as it may have effects on the developing fetus.
  • Rabeprazole should be used during pregnancy only if the potential benefits outweigh the risks, and it is excreted in breast milk. If you are breastfeeding, consult your doctor before using this combination.
• Liver or Kidney Problems:
  • Use caution in patients with liver impairment. Regular monitoring may be required, especially with long-term use.
  • People with kidney impairment should also use this medication cautiously, and the dosage may need to be adjusted.
• Movement Disorders:
  • Levosulpiride may cause movement-related side effects, particularly in those who are more sensitive to dopamine antagonists. If you experience tremors, muscle rigidity, or other abnormal movements, inform your doctor.
• Long-term Use:
  • Rabeprazole can cause low magnesium levels if used long-term, which may lead to muscle cramps, irregular heartbeats, or seizures. It may also increase the risk of gastrointestinal infections, including Clostridium difficile.

Drug Interactions:

• Clopidogrel (blood thinner): Rabeprazole can reduce the effectiveness of clopidogrel, a medication used to prevent blood clots.
• Antacids or H2 blockers: Can reduce the effectiveness of Rabeprazole by raising the stomach pH.
• Levodopa (for Parkinson’s disease): Levosulpiride may interfere with the effects of levodopa, a medication used to treat Parkinson’s disease.
• Antipsychotic medications: Levosulpiride is a dopamine antagonist, so caution is needed when using it with other medications that also affect dopamine pathways.

Storage:

• Store below 30°C in a cool, dry place.
• Keep out of reach of children and avoid storing in excessively humid or hot environments.