Udiliv 450mg Tablet

Udiliv 450mg Tablet is a prescription medication manufactured by Abbott India Ltd. It contains Ursodeoxycholic Acid (450 mg) as its active ingredient. This medication is used primarily for treating liver and gallbladder disorders, including those related to bile acids and cholesterol.

Composition:

• Ursodeoxycholic Acid (450 mg) – The active ingredient in Udiliv 450mg Tablet. Ursodeoxycholic acid, also known as Ursodiol, is a naturally occurring bile acid that plays a key role in reducing cholesterol content in bile and improving liver function.

Mechanism of Action:

• Ursodeoxycholic Acid (UDCA) works through several mechanisms:
  • Reduces cholesterol concentration in bile by inhibiting cholesterol synthesis and increasing its solubility in bile, which helps in dissolving cholesterol-based gallstones.
  • Protects liver cells by reducing the toxic effects of bile acids that can accumulate in liver disease, especially in conditions such as primary biliary cirrhosis (PBC) and cholestasis.
  • Improves bile flow in patients with cholestasis, a condition where bile cannot flow from the liver to the duodenum, leading to liver damage and bile accumulation.

Indications:

Udiliv 450mg Tablet is used to treat the following conditions:

1. Cholesterol Gallstones:
   • UDCA is used to dissolve small, cholesterol-based gallstones in patients who are not candidates for gallbladder surgery.
2. Primary Biliary Cirrhosis (PBC):
   • A chronic liver disease where the bile ducts in the liver are destroyed, leading to liver damage. Ursodeoxycholic acid helps to improve liver function and slow disease progression.
3. Non-Alcoholic Fatty Liver Disease (NAFLD):
   • UDCA is sometimes used to improve liver function in patients with NAFLD, although its use may depend on the severity and other treatment options available.
4. Cholestasis:
   • In conditions where bile flow is impaired (e.g., intrahepatic cholestasis), UDCA helps improve bile flow and reduces the symptoms related to bile acid buildup.
5. Liver Protection:
   • UDCA is used to protect liver cells in various liver disorders where bile acid accumulation can cause damage.

Dosage:

The dosage of Udiliv 450mg Tablet varies based on the specific condition being treated. Common dosage recommendations are as follows:

• For Gallstones: Typically, 450 mg to 900 mg per day (depending on the size and number of stones), taken in divided doses.
• For Primary Biliary Cirrhosis (PBC): The recommended dose is usually 13-15 mg/kg body weight per day, typically divided into two doses.
• For Cholestasis and Liver Protection: The dose may vary based on the severity of the condition and individual response.

Note: The exact dosage and treatment duration should be determined by a healthcare provider based on the patient’s specific condition.

Side Effects:

Udiliv 450mg Tablet is generally well tolerated, but some patients may experience side effects, including:

• Common side effects:
  • Diarrhea
  • Abdominal discomfort or pain
  • Nausea
  • Indigestion
  • Headache
• Serious side effects (rare but may require immediate medical attention):
  • Allergic reactions (e.g., rash, itching, swelling)
  • Fatigue or weakness
  • Yellowing of the skin or eyes (jaundice) — a sign of worsening liver function
  • Liver function abnormalities — Liver tests may need to be monitored during long-term therapy.

If you experience any serious side effects, contact your healthcare provider promptly.

Precautions:

• Pregnancy and Breastfeeding:
  • Ursodeoxycholic acid is generally considered safe during pregnancy (Category B), but it should only be used if clearly needed. Always consult your doctor if you are pregnant or breastfeeding.
• Liver Disease:
  • While Ursodeoxycholic acid is used to treat certain liver diseases, caution should be used in patients with severe liver dysfunction. Liver function should be monitored during treatment.
• Gallstones:
  • Ursodeoxycholic acid is effective for cholesterol gallstones, but not for calcified or large stones. A healthcare provider will evaluate whether UDCA is suitable for gallstone treatment.
• Drug Interactions:
  • Cholestyramine and Colestipol (bile acid sequestrants) may reduce the absorption of UDCA. These medications should be taken at least 1 hour before or 4-6 hours after taking UDCA.
  • Ciclosporin (immunosuppressant used in organ transplant recipients) levels may increase with Ursodeoxycholic acid, so monitoring may be required when both drugs are taken together.
  • Other drugs like estrogens (hormonal contraceptives or replacement therapy) may affect the effectiveness of UDCA in cholesterol gallstone treatment.

Storage:

• Store Udiliv 450mg Tablet at room temperature, below 30°C.
• Keep the tablets in a dry place, away from moisture and heat, and out of reach of children.

Return Policy:

• Udiliv 450mg Tablet is a prescription drug, and as such, it is typically not returnable once purchased.