Targit 40 – strips of 10 Tablets

Description

Targit 40 – strips of 10 Tablets

(Telmisartan 40mg, Strip of 15 Uncoated Tablets)

1. Active Ingredient

• Telmisartan IP – 40mg (Angiotensin II Receptor Blocker/ARB)

2. Key Characteristics

• Class: Non-peptide ARB (AT1 subtype selective)

• Bioavailability: 42% (high fat meal increases absorption by 6-20%)

• Half-life: 24 hours (permits once-daily dosing)

• Protein Binding: >99.5% (mainly to albumin)

3. Approved Indications

✔ Hypertension (First-line treatment)
✔ Cardiovascular Risk Reduction in patients unable to take ACE inhibitors
✔ Diabetic Nephropathy (off-label use in India)

4. Dosage & Administration

• Standard Dose: 40mg once daily (may increase to 80mg)

• Best Taken: With/without food (consistent timing recommended)

• Crushing: Not recommended (uncoated but not scored)

5. Mechanism of Action

• Selectively blocks AT1 receptors →

  • Vasodilation (reduced peripheral resistance)

  • Decreased aldosterone secretion

  • No effect on bradykinin metabolism (unlike ACE inhibitors)

6. Advantages Over Other ARBs

✓ Longest half-life (24 hrs vs Losartan’s 6-9 hrs)
✓ PPAR-γ modulation (additional metabolic benefits)
✓ Renal excretion <1% (safer in renal impairment)

7. Contraindications

✖ Bilateral renal artery stenosis
✖ Severe hepatic impairment (Child-Pugh C)
✖ Pregnancy (FDA Category D in 2nd/3rd trimesters)

8. Drug Interactions

⚠ NSAIDs: Reduced antihypertensive effect
⚠ Digoxin: May increase serum levels (monitor)
⚠ Ramipril: Increased risk of hyperkalemia

9. Adverse Effects

• Common (≥1%):

  • Dizziness (3.1%)

  • Back pain (2.9%)

  • Sinusitis (2.3%)

• Serious (Rare):

  • Angioedema (<0.1%)

  • Hyperkalemia (risk in CKD patients)

10. Special Populations

• Elderly: No dose adjustment needed

• Renal Impairment: Safe down to CrCl 15ml/min

• Hepatic Impairment: Max 40mg/day in Child-Pugh B

11. Storage Conditions

• Temperature: Below 30°C

• Protection: Keep in original blister

• Shelf Life: Typically 36 months

12. Market Position

• Price Range: ₹120-150 per strip (15 tablets)

• Comparable Brands:

  • Telma (Glenmark)

  • Telsartan (Sun Pharma)

  • Telvas (Aristo Pharma)

13. Clinical Pearls

• Preferred in Metabolic Syndrome:
  Shows PPAR-γ activity → improves insulin sensitivity

• Morning vs Bedtime Dosing:
  Evening administration may better control nocturnal BP

14. Manufacturer Details

• Marketing Authorization Holder: Pfizer Limited

• Manufacturing Site: Likely Goa plant (FDA-approved facility)

15. Available Strengths

• Other variants: Targit 20 (20mg), Targit 80 (80mg)

Therapeutic Alternatives