Description

Sitaxa Dm 10/100/500 – Strip of 10 Tablets

Sitaxa DM 10/100/500 is a combination medication used for the management of type 2 diabetes mellitus. It contains three active ingredients: Sitagliptin, Metformin, and Glimepiride. Each of these medications plays a different role in controlling blood sugar levels.

Active Ingredients:

1. Sitagliptin (10 mg):
   • Sitagliptin is a DPP-4 inhibitor (Dipeptidyl Peptidase-4 inhibitor). It works by increasing the levels of incretin hormones, which stimulate insulin production when blood glucose levels are high. Additionally, it reduces the amount of glucose produced by the liver.
2. Metformin (500 mg):
   • Metformin is a biguanide that helps lower blood sugar levels by:
     • Decreasing the production of glucose in the liver.
     • Increasing insulin sensitivity in muscle and fat cells, allowing them to use glucose more effectively.
     • Reducing glucose absorption in the intestines.
3. Glimepiride (10 mg):
   • Glimepiride is a sulfonylurea. It works by increasing the release of insulin from the pancreas. This helps lower blood glucose levels, particularly after meals. It enhances insulin sensitivity in the body, aiding in better glucose control.

Indications:

Sitaxa DM 10/100/500 is used for:

• Type 2 diabetes mellitus: It is prescribed when diet, exercise, and other medications are insufficient in controlling blood sugar levels.
• Improved glycemic control: The combination of Sitagliptin, Metformin, and Glimepiride helps provide better overall blood glucose control by acting through different mechanisms.

Dosage:

• The usual dose of Sitaxa DM 10/100/500 is 1 tablet per day, but your doctor may adjust the dose based on your blood glucose levels and individual response.
• It is typically recommended to take this medication with food to reduce gastrointestinal side effects, especially from Metformin.
• Sitaxa DM 10/100/500 is available in a strip of 10 tablets, and the dosage may be increased gradually if needed, under medical supervision.

Side Effects:

Like all medications, Sitaxa DM 10/100/500 may cause side effects. These include:

• Common side effects:
  • Gastrointestinal issues: Nausea, diarrhea, abdominal discomfort, and loss of appetite (commonly with Metformin).
  • Headache or dizziness.
  • Hypoglycemia (low blood sugar): Especially when used with other blood sugar-lowering medications like insulin or sulfonylureas.
• Serious side effects (requires immediate medical attention):
  • Lactic acidosis: A rare but serious condition caused by Metformin, leading to muscle pain, weakness, difficulty breathing, dizziness, or feeling cold.
  • Pancreatitis: Severe abdominal pain, which may indicate inflammation of the pancreas. Seek medical help immediately if this occurs.
  • Severe hypoglycemia: Symptoms include confusion, sweating, dizziness, and shakiness, particularly when combined with other medications.
  • Allergic reactions: Rash, swelling, or difficulty breathing may indicate an allergy to any of the components.

Precautions:

• Kidney or liver function: As Metformin and Sitagliptin are processed by the kidneys, regular monitoring of kidney function is essential. People with kidney or liver problems may need adjusted doses or an alternative treatment.
• Hypoglycemia: The risk of low blood sugar may be higher when using Glimepiride, especially if combined with other insulin or sulfonylurea medications. Symptoms of hypoglycemia should be managed immediately by consuming fast-acting carbohydrates (e.g., fruit juice or glucose tablets).
• Alcohol: Alcohol can increase the risk of lactic acidosis when taking Metformin. It should be consumed in moderation or avoided.
• Pregnancy and breastfeeding: Consult your doctor before using Sitaxa DM 10/100/500 during pregnancy or breastfeeding, as the safety of this medication during these times is not well established.

Warnings:

• Lactic acidosis: A rare but life-threatening condition associated with Metformin. If you notice symptoms such as muscle pain, difficulty breathing, or unusual tiredness, contact your healthcare provider immediately.
• Pancreatitis: Sitagliptin may increase the risk of pancreatitis, though it is rare. Seek immediate medical attention if you experience severe abdominal pain.
• Hypoglycemia: The risk of low blood sugar is higher when Glimepiride is combined with other diabetes medications. Regular blood sugar monitoring is essential to avoid this condition.