Description

Sitaxa D 10/100 – Strip of 10 Tablets

Sitaxa D 10/100 is a combination medication used primarily for the management of type 2 diabetes mellitus. It contains Sitagliptin and Metformin as its active ingredients, each playing a crucial role in controlling blood sugar levels in individuals with diabetes.

Active Ingredients:

1. Sitagliptin (10 mg):
   • Sitagliptin is a DPP-4 inhibitor (Dipeptidyl Peptidase-4 inhibitor). It works by increasing the levels of incretin hormones, which help stimulate insulin production in response to meals and reduce the amount of glucose produced by the liver. This helps control blood sugar levels, especially after eating.
2. Metformin (1000 mg):
   • Metformin is a biguanide that helps lower blood glucose by:
     • Reducing the production of glucose in the liver.
     • Increasing insulin sensitivity in muscle and fat cells, enabling the body to use glucose more efficiently.
     • Decreasing glucose absorption from the intestines, which helps manage post-meal blood sugar spikes.

Indications:

Sitaxa D 10/100 is prescribed to:

• Adults with type 2 diabetes mellitus when diet and exercise alone are insufficient in controlling blood glucose levels.
• For improved glycemic control: It combines the action of Sitagliptin and Metformin to manage both fasting and post-meal blood sugar levels.

Dosage:

• The typical starting dose is 1 tablet per day, taken with food to reduce the risk of gastrointestinal side effects, especially from Metformin.
• The dose may be adjusted by your doctor depending on your blood sugar levels and tolerance to the medication.
• It is generally recommended to take Sitaxa D 10/100 once daily. However, your healthcare provider may decide to modify this based on your individual condition.

Side Effects:

Common side effects include:

• Gastrointestinal issues such as nausea, diarrhea, abdominal discomfort, and loss of appetite (more common with Metformin).
• Headache or dizziness.
• Low blood sugar (hypoglycemia): This can occur when Sitaxa D 10/100 is used in combination with other blood sugar-lowering medications, like insulin or sulfonylureas.

Serious side effects include:

• Lactic acidosis: This is a rare but serious condition associated with Metformin, which can cause symptoms like muscle pain, difficulty breathing, dizziness, or feeling cold. Seek immediate medical help if these occur.
• Pancreatitis: Severe abdominal pain, which may be indicative of inflammation of the pancreas. Immediate medical attention is required.
• Severe hypoglycemia: Symptoms of low blood sugar, such as confusion, sweating, shaking, dizziness, and hunger, require prompt attention.

Precautions:

• Kidney Function: Both Sitagliptin and Metformin are processed by the kidneys. It is important to monitor kidney function regularly, especially for patients with existing kidney problems, as the medication may need to be adjusted or avoided in cases of severe kidney impairment.
• Hypoglycemia: The combination of Metformin and Sitagliptin does not generally cause hypoglycemia by itself, but the risk increases if used with other antidiabetic drugs, especially Glimepiride, Insulin, or Sulfonylureas.
• Alcohol: Excessive alcohol intake increases the risk of lactic acidosis with Metformin. It is advisable to limit alcohol consumption while using this medication.
• Pregnancy and breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, consult your doctor before taking Sitaxa D 10/100. The safety of this medication during pregnancy and breastfeeding has not been fully established.

Warnings:

• Lactic acidosis: A rare but potentially fatal condition caused by Metformin, characterized by symptoms like unusual muscle pain, weakness, trouble breathing, dizziness, or feeling cold. Seek immediate medical attention if you experience these signs.
• Pancreatitis: If you experience severe abdominal pain, discontinue Sitaxa D 10/100 and consult a healthcare provider immediately.
• Kidney function monitoring: As both Sitagliptin and Metformin are eliminated through the kidneys, kidney function should be regularly monitored, especially for those with pre-existing kidney conditions.