Sitabite 50 mg Tablets 10′

Description

Sitabite 50 mg is a medication that contains Sitagliptin as its active ingredient. Sitagliptin is an oral antidiabetic drug primarily used to manage type 2 diabetes. It works by increasing insulin release and decreasing the amount of sugar produced by the liver, helping to control blood glucose (sugar) levels.

Active Ingredient:

• Sitagliptin 50 mg per tablet

Uses of Sitabite 50 mg (Sitagliptin):

Sitabite is used to treat type 2 diabetes in combination with diet and exercise to help control blood sugar levels. It can be used alone or with other medications (including metformin, sulfonylureas, or insulin).

1. Type 2 Diabetes:
   • Sitagliptin is used to improve blood sugar control in adults with type 2 diabetes. It works by affecting the body’s levels of incretins—hormones that help regulate blood sugar.
2. Combination Therapy:
   • It is often used in combination with other oral diabetes medications (e.g., metformin, sulfonylureas) or insulin when blood sugar control cannot be achieved with one medication alone.
3. Adjunct to Diet and Exercise:
   • Sitagliptin is always used along with a healthy diet and regular exercise to manage blood glucose levels in type 2 diabetes patients.

How Sitabite 50 mg (Sitagliptin) Works:

Sitagliptin belongs to a class of medications called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors). It works by:

1. Increasing Insulin Secretion:
   • After meals, incretin hormones (like GLP-1) are released from the intestine and stimulate insulin release from the pancreas. Sitagliptin increases the levels of these hormones by inhibiting the enzyme DPP-4, which normally breaks down incretins. This leads to better insulin secretion in response to meals, helping reduce blood sugar.
2. Decreasing Glucose Production:
   • Sitagliptin also works to reduce glucose production in the liver, thereby lowering the amount of sugar released into the bloodstream.
3. Lowering Blood Sugar:
   • By increasing insulin and reducing liver glucose output, Sitagliptin helps lower fasting blood sugar and post-meal blood sugar levels.

Dosage and Administration:

• Usual Adult Dose:
  • The standard dose of Sitabite (Sitagliptin) is 50 mg taken once daily, typically with or without food.
  • The dose can vary depending on your kidney function and your doctor’s recommendation. In patients with moderate kidney impairment, the dose is typically reduced to 25 mg daily.
• For kidney problems:
  • If you have kidney disease, your doctor will adjust the dose based on your kidney function. Sitagliptin is generally not recommended for use in patients with severe kidney impairment (e.g., end-stage renal disease or on dialysis).
• Missed Dose:
  • If you miss a dose, take it as soon as you remember unless it is almost time for your next dose. Do not take two doses to make up for a missed dose.

Side Effects of Sitabite 50 mg (Sitagliptin):

Like all medications, Sitagliptin can cause side effects, although not everyone experiences them. Common and serious side effects include:

1. Common Side Effects:
   • Headache
   • Nasal congestion or upper respiratory tract infection
   • Sore throat
   • Stomach discomfort (e.g., indigestion, nausea)
   • Diarrhea or constipation
2. Serious Side Effects (Rare):
   • Pancreatitis (inflammation of the pancreas): Symptoms include severe abdominal pain, nausea, and vomiting.
   • Severe allergic reactions: Including rash, itching, swelling of the face, lips, or throat, and difficulty breathing. If any of these occur, seek medical help immediately.
   • Kidney problems: Signs of kidney issues can include swelling of the legs or feet, changes in urination, or fatigue.
   • Joint pain: Some people may experience severe muscle or joint pain.
   • Hypoglycemia (low blood sugar): This is rare but may occur, especially if Sitagliptin is used with other antidiabetic drugs like insulin or sulfonylureas. Symptoms of hypoglycemia include shaking, sweating, fast heartbeat, and dizziness.
3. Rare Side Effects:
   • Bladder infections or urinary tract infections (UTIs)
   • Rash or itching
   • Liver enzyme abnormalities: Rare but serious liver issues can arise, such as jaundice (yellowing of the skin or eyes), dark urine, or abdominal pain.

Precautions and Warnings:

Before taking Sitabite 50 mg, discuss the following precautions with your healthcare provider:

1. Kidney Disease:
   • Sitagliptin is cleared by the kidneys, so if you have any kidney problems, your doctor may adjust the dose. For people with severe kidney issues, Sitagliptin may not be suitable.
2. Pancreatitis:
   • Sitagliptin has been associated with a risk of pancreatitis. If you have a history of pancreatitis, your doctor will assess whether Sitagliptin is right for you.
3. Allergic Reactions:
   • Although rare, Sitagliptin can cause serious allergic reactions. Seek immediate medical attention if you experience symptoms such as swelling, rash, or difficulty breathing.
4. Hypoglycemia:
   • Sitagliptin itself does not usually cause low blood sugar. However, if it is used in combination with other medications like insulin or sulfonylureas, the risk of hypoglycemia (low blood sugar) can increase. Be aware of the signs of hypoglycemia (such as dizziness, sweating, confusion) and treat it promptly by consuming a fast-acting source of sugar.
5. Heart Conditions:
   • If you have a history of heart conditions, particularly heart failure, discuss this with your doctor. Some studies suggest an increased risk of hospitalization for heart failure with certain medications for diabetes, including Sitagliptin.
6. Pregnancy and Breastfeeding:
   • Pregnancy: Sitagliptin should be used during pregnancy only if clearly needed. Discuss any potential risks with your healthcare provider.
   • Breastfeeding: It is not known whether Sitagliptin passes into breast milk, so consult your doctor before using it while breastfeeding.

Drug Interactions:

Sitagliptin can interact with other medications, so it’s important to inform your healthcare provider about all the medicines you are currently taking, including over-the-counter drugs and supplements.

1. Other Antidiabetic Medications: Combining Sitagliptin with insulin or sulfonylureas may increase the risk of hypoglycemia. Your doctor may adjust the doses of these medications accordingly.
2. Rifampin (an antibiotic) may reduce the effectiveness of Sitagliptin by increasing its clearance from the body.
3. Immunosuppressive Drugs: Sitagliptin may interact with certain immunosuppressive medications, so careful monitoring may be needed if you are on those drugs.
4. Digoxin: Sitagliptin may slightly increase the blood levels of digoxin, a medication used for heart conditions. This combination may require monitoring.

Storage:

• Store Sitabite 50 mg tablets at room temperature (15°C to 30°C), away from heat and moisture. Keep the medication in its original packaging and out of reach of children.
• Do not use the medication after its expiration date.