Description
Rozucor Gold 20 is a combination medication used primarily for cardiovascular protection, especially in individuals at high risk of heart attack or stroke. Here’s a breakdown of its composition and what each component does:
Composition per capsule (as per your input):
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Rosuvastatin (as pellets) – 20 mg
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Type: Statin (lipid-lowering agent)
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Purpose: Lowers LDL cholesterol, raises HDL cholesterol, and reduces triglycerides.
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Use: Prevents plaque build-up in arteries (atherosclerosis) and lowers risk of heart attack or stroke.
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Aspirin I.P. (as gastro-resistant pellets) – 75 mg
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Type: Antiplatelet (NSAID)
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Purpose: Prevents platelets from clumping together to form clots.
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Use: Reduces risk of blood clots, heart attack, and stroke.
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Note: The gastro-resistant coating helps reduce stomach irritation or ulcers.
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Clopidogrel Bisulphate I.P. equivalent to Clopidogrel (as pellets) – 75 mg
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Type: Antiplatelet
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Purpose: Inhibits platelet aggregation to prevent clot formation.
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Use: Commonly prescribed after heart attacks, strokes, or stent placement.
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Excipients – q.s. (quantum satis)
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Inactive substances used as carriers or stabilizers.
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Therapeutic Uses:
Rozucor Gold 20 is often prescribed for:
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Secondary prevention of cardiovascular events (e.g., after a heart attack or stroke)
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Patients with high cholesterol and other risk factors like hypertension, diabetes, or smoking
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After angioplasty or stent placement
Important Notes:
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Take as directed by your physician—usually once daily, preferably with food (to minimize GI side effects).
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Do not crush or chew the capsules (especially due to the enteric-coated aspirin).
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Regular monitoring of liver function and lipid levels may be needed.
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Watch for signs of bleeding (gums, bruises, black stools) due to antiplatelet agents
🧪 Composition (per capsule):
| Ingredient | Quantity | Form | Purpose |
|---|---|---|---|
| Rosuvastatin (as pellets) | 20 mg | Lipid-lowering agent (statin) | Reduces LDL (“bad”) cholesterol, raises HDL, lowers triglycerides |
| Aspirin I.P. (as gastro-resistant pellets) | 75 mg | Antiplatelet (NSAID) | Prevents clot formation by inhibiting platelet aggregation |
| Clopidogrel Bisulphate I.P. (eq. to Clopidogrel as pellets) | 75 mg | Antiplatelet | Inhibits ADP-mediated platelet aggregation, reducing risk of clot formation |
| Excipients | q.s. (quantum satis) | Inactive ingredients | Used for formulation stability and delivery |
🎯 Pharmacological Class:
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Rosuvastatin – HMG-CoA reductase inhibitor (Statin)
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Aspirin – Nonsteroidal anti-inflammatory drug (NSAID) with antiplatelet effect
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Clopidogrel – Thienopyridine class antiplatelet
🩺 Therapeutic Indications (Uses):
Rozucor Gold 20 is used for cardiovascular protection in patients at risk of or with a history of:
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Myocardial infarction (heart attack)
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Ischemic stroke
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Acute coronary syndrome
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Atherosclerosis
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Post-angioplasty or coronary stenting
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Hyperlipidemia or dyslipidemia
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Diabetes or hypertension with cardiovascular risk
🕒 Dosage & Administration:
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Dosage: One capsule once daily, or as prescribed by a doctor.
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Administration: Swallow whole with water, preferably with food to reduce gastric side effects.
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Do not crush or chew, as it may affect the enteric coating of aspirin.
⚠️ Warnings & Precautions:
1. Bleeding Risk:
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Aspirin and Clopidogrel both inhibit platelet function.
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Increased risk of bleeding, especially GI bleeding or intracranial hemorrhage.
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Avoid with other anticoagulants unless advised.
2. Liver Function:
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Rosuvastatin can affect liver enzymes.
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Monitor LFTs periodically, especially in long-term use.
3. Kidney Function:
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Use with caution in patients with renal impairment.
4. Gastrointestinal Irritation:
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Even with enteric coating, aspirin may cause GI upset or ulcers.
5. Allergy:
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Contraindicated in individuals with aspirin sensitivity, asthma with NSAID hypersensitivity, or severe allergic reactions to any component.
🔄 Drug Interactions:
Can interact with:
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Warfarin or other anticoagulants (↑ bleeding risk)
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Other NSAIDs (↑ GI irritation)
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Proton pump inhibitors (may reduce Clopidogrel efficacy)
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Cyclosporine, gemfibrozil (↑ risk of statin-related side effects)
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Antacids (can reduce Rosuvastatin absorption; separate by 2 hours)
🚫 Contraindications:
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Active bleeding disorders
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Severe hepatic impairment
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History of hemorrhagic stroke
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Pregnancy and lactation (Rosuvastatin is contraindicated)
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Known allergy to any of the three drugs
⚠️ Common Side Effects:
| System | Possible Side Effects |
|---|---|
| Gastrointestinal | Nausea, dyspepsia, abdominal pain, gastritis, bleeding |
| Musculoskeletal | Muscle pain, weakness (statin-induced myopathy or rarely rhabdomyolysis) |
| Hematologic | Easy bruising, bleeding gums, nosebleeds |
| Neurologic | Headache, dizziness |
| Others | Liver enzyme elevation, rash, fatigue |
👩⚕️ Monitoring Parameters:
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Lipid profile
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Liver function tests (ALT, AST)
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CK levels if muscle pain occurs
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Signs of bleeding
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Renal function (especially in elderly)
📦 Packaging:
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Typically comes in a strip of 10 capsules.
🏷️ Storage:
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Store in a cool, dry place, below 25°C.
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Protect from light and moisture.
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Keep out of reach of children.
🧾 Legal Status (India):
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Schedule H drug – Prescription only.
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