Description

Remo-Zen M 500 Tablet

Remo-Zen M 500 Tablet is a combination oral antidiabetic medication used for the management of type 2 diabetes mellitus. It contains:

• Remogliflozin Etabonate 100 mg – an SGLT2 inhibitor

• Metformin Hydrochloride IP 500 mg – a Biguanide

This combination provides dual action to improve blood sugar control in patients whose glucose levels are not adequately managed by diet, exercise, or monotherapy. The film-coated tablet ensures easy swallowing and optimal absorption.

. Composition

. Mechanism of Action

A. Remogliflozin Etabonate (SGLT2 Inhibitor)

• Inhibits sodium-glucose co-transporter 2 in kidneys.

• Reduces renal glucose reabsorption.

• Increases glucose excretion in urine.

• Lowers fasting and postprandial blood sugar levels.

. Metformin Hydrochloride (Biguanide)

• Reduces hepatic gluconeogenesis.

• Increases peripheral insulin sensitivity.

• Improves glucose uptake by muscles.

• Minimal risk of hypoglycemia when used alone.

The combination works via complementary mechanisms, targeting both renal glucose excretion and insulin sensitivity.

. Pharmacokinetics

• Absorption: Oral, well-absorbed; Metformin absorption mainly in small intestine.

• Distribution: Metformin minimally protein-bound; Remogliflozin moderately bound.

• Metabolism: Remogliflozin metabolized in liver; Metformin excreted unchanged in urine.

• Excretion: Primarily via urine.

• Half-life: Suitable for once or twice daily dosing, depending on physician recommendation.

. Indications / Therapeutic Uses

• Type 2 diabetes mellitus patients with inadequate glycemic control using diet and exercise.

• Can be used as initial combination therapy or as add-on therapy to monotherapy.

• Helps reduce fasting plasma glucose, postprandial glucose, and HbA1c levels.

. Dosage and Administration

• Adults: 1 tablet once or twice daily, preferably with meals (to reduce gastrointestinal side effects of Metformin).

• Swallow whole; do not chew or crush.

• Dose adjustments may be needed for renal impairment, elderly, or hepatic dysfunction.

. Benefits of Combination Therapy

• Dual mechanism of action: renal glucose excretion + insulin sensitization.

• Effective glycemic control for both fasting and postprandial glucose.

• Convenient single tablet therapy, reducing pill burden.

• May reduce side effects compared to higher doses of individual drugs.

. Side Effects

• Gastrointestinal: nausea, diarrhea, abdominal discomfort (mainly Metformin).

• Genitourinary: urinary tract infections (Remogliflozin).

• Rare: lactic acidosis (Metformin), dehydration, hypotension.

• Usually mild and transient; serious adverse effects are rare.

. Precautions

• Monitor renal and liver function regularly.

• Maintain adequate hydration to prevent dehydration and urinary infections.

• Not recommended in type 1 diabetes or diabetic ketoacidosis.

• Use in pregnancy/lactation only if prescribed.

. Storage Conditions

• Store in a cool, dry place, below 30°C.

• Protect from light and moisture.

• Keep out of reach of children.

. Alternate Brand Options (Remogliflozin + Metformin 500 mg)

Prices are approximate and may vary by pharmacy and location.

Remo-Zen M 500 Tablet is a dual-action oral antidiabetic medication combining Remogliflozin and Metformin. Its complementary mechanisms — renal glucose excretion plus improved insulin sensitivity — make it effective for managing type 2 diabetes mellitus. The combination provides convenient dosing, better glycemic control, and options for cost-effective alternatives through multiple brands.