Rablet D Capsule SR

Description

Rablet D Capsule SR is a prescription medication marketed by Lupin Ltd. It combines two active ingredients: Domperidone (30 mg) and Rabeprazole (20 mg). This formulation is used for managing gastrointestinal conditions that involve acid reflux and impaired gastric motility.

Composition:

• Domperidone (30 mg): A dopamine antagonist that helps in improving gastrointestinal motility and reducing nausea and vomiting.
• Rabeprazole (20 mg): A proton pump inhibitor (PPI) that reduces stomach acid production.

Mechanism of Action:

1. Rabeprazole inhibits the proton pumps in the stomach, which reduces the production of gastric acid. This is particularly helpful in conditions like gastroesophageal reflux disease (GERD) and peptic ulcers, where excess stomach acid can cause damage.
2. Domperidone works by blocking dopamine receptors in the gastrointestinal tract, which promotes motility (i.e., helps food move through the stomach and intestines more efficiently). It also helps to prevent nausea and vomiting, which can be a concern in conditions like gastroparesis (delayed stomach emptying).

Indications:

Rablet D Capsule SR is typically prescribed for:

• Gastroesophageal reflux disease (GERD): To reduce symptoms like heartburn, acid regurgitation, and inflammation in the esophagus caused by stomach acid.
• Peptic ulcers and gastritis: Helps reduce stomach acid to aid in the healing of ulcers and inflammation in the stomach lining.
• Dyspepsia (Indigestion): Relieves discomfort, bloating, and nausea associated with indigestion.
• Gastroparesis: Helps to accelerate gastric emptying and reduce symptoms of delayed stomach motility, such as nausea and bloating.
• Nausea and vomiting associated with gastrointestinal disorders.

Dosage:

The typical dose is one capsule daily, usually taken before a meal. However, the exact dosage and duration should be determined by a healthcare provider based on the specific condition and individual response.

Side Effects:

Common side effects may include:

• Headache
• Nausea or vomiting
• Abdominal discomfort or pain
• Diarrhea or constipation
• Dry mouth or a bitter taste in the mouth

Less common but serious side effects include:

• Movement disorders (e.g., tremors, muscle stiffness) due to domperidone
• Severe allergic reactions (e.g., rash, swelling, difficulty breathing)
• Liver dysfunction (uncommon but requires monitoring)
• QT prolongation (a heart rhythm disorder), especially if combined with other drugs that affect heart rhythm.

Precautions:

• Pregnancy and breastfeeding: Should only be used during pregnancy if the potential benefit justifies the risk. Rabeprazole and domperidone may pass into breast milk, so breastfeeding mothers should consult their doctor before using this medication.
• Kidney or liver impairment: Use with caution in patients with liver or kidney problems. A dose adjustment may be required.
• Cardiac issues: Domperidone can affect the heart’s electrical activity, so it’s typically avoided in patients with existing heart conditions, especially those with a history of arrhythmia or other heart problems.
• Long-term use: Prolonged use of PPIs like rabeprazole can increase the risk of gastrointestinal infections, bone fractures, and kidney issues. Monitoring by a healthcare provider is recommended for long-term use.

Drug Interactions:

• Antacids or H2 blockers: They can interfere with the action of rabeprazole by raising stomach pH, so they should be used cautiously in combination.
• Clopidogrel (a blood thinner): Rabeprazole may reduce the effectiveness of clopidogrel, potentially increasing the risk of blood clots.
• Cyclosporine or methotrexate: Rabeprazole can increase the blood levels of certain drugs, which may increase their toxicity.