Rablet 20 Tablet 15′

Rablet 20 Tablet is a prescription medication marketed by Lupin Ltd. It contains Rabeprazole (20 mg), which is a proton pump inhibitor (PPI) used primarily to reduce the production of stomach acid. Here’s an overview of the medication:

Composition:

• Rabeprazole (20 mg) – The active ingredient. It works by inhibiting the proton pumps in the stomach lining, thereby reducing the secretion of gastric acid.

Mechanism of Action:

Rabeprazole works by irreversibly binding to the H+/K+ ATPase pump (also known as the proton pump) in the parietal cells of the stomach. This pump is responsible for the final step in the production of gastric acid. By inhibiting this pump, Rabeprazole reduces the amount of stomach acid produced, which helps in treating conditions related to excessive acid secretion.

Indications:

Rablet 20 Tablet is typically prescribed for the following conditions:

• Gastroesophageal Reflux Disease (GERD): Helps relieve heartburn and acid regurgitation caused by stomach acid flowing back into the esophagus.
• Peptic Ulcers: Aids in healing ulcers in the stomach and duodenum by reducing stomach acid.
• Helicobacter pylori Eradication (in combination with antibiotics): Used as part of a treatment regimen to eliminate H. pylori infection, which is associated with peptic ulcers.
• Zollinger-Ellison Syndrome: A rare condition where the stomach produces excess acid due to tumors in the pancreas or duodenum.
• Gastritis: Used to reduce inflammation and irritation in the stomach lining caused by excessive acid production.

Dosage:

The usual dose for Rablet 20 Tablet is 20 mg once daily, taken before a meal. The exact duration and dosage may depend on the condition being treated:

• For GERD: 20 mg once daily for 4-8 weeks.
• For peptic ulcers: 20 mg once daily for up to 4-6 weeks.
• For H. pylori eradication: Typically part of a combination therapy that may include antibiotics.

Always follow the instructions provided by your healthcare provider.

Side Effects:

Common side effects of Rabeprazole include:

• Headache
• Nausea or vomiting
• Abdominal pain or discomfort
• Diarrhea or constipation
• Flatulence (gas)

Less common but serious side effects can include:

• Severe allergic reactions (rash, itching, swelling, difficulty breathing)
• Liver dysfunction (uncommon but may require monitoring)
• Low magnesium levels (which can cause muscle cramps, seizures, or abnormal heart rhythms)
• Bone fractures (with long-term use)

If you experience any severe side effects, contact your doctor immediately.

Precautions:

• Pregnancy and Breastfeeding: Rabeprazole should be used during pregnancy only if absolutely necessary, and it is excreted in breast milk, so caution is advised for breastfeeding mothers.
• Kidney and Liver Problems: People with liver impairment should use Rabeprazole with caution and may need dose adjustments. It’s also used with caution in those with kidney disease.
• Long-term Use: Prolonged use of PPIs like rabeprazole can lead to an increased risk of bone fractures, gastrointestinal infections (e.g., C. difficile), and low magnesium levels. If you need long-term treatment, your healthcare provider may monitor you for these risks.
• Interaction with Other Medications: Rabeprazole may interact with certain medications, including:
  • Clopidogrel (blood thinner): Rabeprazole can reduce the effectiveness of clopidogrel.
  • Methotrexate: Rabeprazole may increase methotrexate levels, increasing the risk of toxicity.
  • Drugs affecting stomach acid (e.g., antacids, H2 blockers): May interfere with the action of Rabeprazole.

Drug Interactions:

• Clopidogrel (blood thinner): Rabeprazole may reduce the effectiveness of clopidogrel, which could increase the risk of blood clots.
• Antacids: While antacids can reduce stomach acid, they may affect the absorption of Rabeprazole.
• Methotrexate: Rabeprazole may elevate the blood levels of methotrexate, increasing the risk of toxicity.
• Warfarin (anticoagulant): Caution is advised, as Rabeprazole may increase the effects of blood thinners like warfarin, potentially raising the risk of bleeding.