PATIF MAX EYE DROP

Description

Patif Max Eye Drop is an ophthalmic anti-allergic formulation used for the treatment of allergic conjunctivitis and associated symptoms like itching, redness, watering, and irritation. It contains Pemirolast Potassium 0.2% w/v, which is a mast cell stabilizer. This is a higher-strength version compared to the standard Patif Eye Drop (0.1%), offering enhanced control for moderate to severe allergy symptoms.

Composition

• Pemirolast Potassium 0.2% w/v

• Sterile aqueous base

• Preservatives and stabilizers (varies by manufacturer)

Pharmacological Class

• Anti-allergic ophthalmic agent

• Mast cell stabilizer

• Non-steroidal and non-vasoconstrictive

Mechanism of Action

Pemirolast Potassium primarily works by stabilizing mast cells in the conjunctiva. Mast cells are responsible for releasing allergic mediators such as:

• Histamine

• Leukotrienes

• Prostaglandins

• Cytokines

When allergens like dust, pollen, or pet dander enter the eye, mast cells release these substances, causing itching, redness, swelling, and watery discharge.

Pemirolast inhibits calcium influx into mast cells, a crucial step required for degranulation. By preventing this release, it blocks the early and late phases of the allergic response. This action helps control symptoms and reduces the severity and frequency of allergy episodes.

Uses / Indications

Patif Max Eye Drop is mainly used for:

• Seasonal Allergic Conjunctivitis (SAC) – symptoms triggered by seasonal allergens such as pollen.

• Perennial Allergic Conjunctivitis (PAC) – year-round allergies due to dust mites, molds, or pet dander.

• Irritant Allergic Reactions – due to smoke, pollution, or environmental allergens.

Its higher concentration makes it suitable for individuals experiencing stronger or persistent allergic symptoms.

Pharmacokinetics

• Acts locally in the eye with minimal systemic absorption.

• Onset of effect occurs within a few hours of instillation.

• The drug distributes across conjunctival tissues and is eliminated gradually via tear turnover and mild metabolic processes.

• Because systemic absorption is negligible, systemic side effects are rare.

Formulation Characteristics

Patif Max is presented as a clear, sterile aqueous solution, optimized for ocular comfort.
The LDPE bottle includes a built-in dropper for controlled dosing.
The solution is isotonic and buffered to match the natural pH of the eye, reducing irritation.

Common Side Effects

Although generally well-tolerated, some individuals may experience:

• Mild burning or stinging upon instillation

• Temporary blurred vision

• Watery eyes

• Mild irritation or foreign-body sensation

• Redness or dryness in some cases

These effects are typically short-lived and occur due to the sensitivity of ocular tissues to instilled drops.

Storage

Patif Max Eye Drop is usually stored at room temperature, kept tightly closed, and protected from direct light to maintain sterility and stability.