Prostagard-D 4 – strip of 10 Tablets

Description

Prostagard-D 4 – strip of 10 Tablets

Composition:

• Silodosin 4 mg
• Dutasteride IP 0.5 mg
• Excipients q.s.

Prostagard-D 4 is a combination therapy used for the management of Benign Prostatic Hyperplasia (BPH), a condition where the prostate gland enlarges and obstructs normal urine flow. The medication combines the benefits of an alpha-blocker (Silodosin) and a 5-alpha reductase inhibitor (Dutasteride) to provide both immediate and long-term relief from urinary symptoms.

2. Composition & Nature of Ingredients

Silodosin 4 mg

A selective alpha-1A adrenergic receptor blocker that relaxes smooth muscles in the prostate and bladder neck.

Dutasteride 0.5 mg

A 5-alpha reductase inhibitor that reduces the conversion of testosterone into dihydrotestosterone (DHT), helping shrink the prostate gland gradually.

3. Mechanism of Action

Silodosin

• Targets alpha-1A receptors in the prostate region.
• Relaxes smooth muscles in the prostate, urethra, and bladder outlet.
• Provides rapid relief from urinary symptoms by reducing resistance to urine flow.

Dutasteride

• Blocks both Type-1 and Type-2 5-alpha reductase enzymes.
• Lowers DHT levels responsible for prostate enlargement.
• Gradually reduces prostate size over time.
• Helps prevent worsening of BPH and reduces the risk of acute urinary retention.

4. Indications

Used for the treatment of Benign Prostatic Hyperplasia (BPH), including:

• Weak urine stream
• Frequent urination
• Nocturia (night-time urination)
• Difficulty starting urination
• Straining and dribbling
• Sensation of incomplete bladder emptying

5. Therapeutic Benefits

• Provides both short-term and long-term relief.
• Silodosin improves urine flow within days.
• Dutasteride shrinks the prostate gradually over months.
• Reduces urinary urgency and frequency.
• Helps improve bladder emptying.
• Lowers risk of urinary retention and future surgical intervention.

6. Pharmacological Profile

Silodosin

• Rapid onset of action
• Highly selective for urinary tract receptors
• Minimal effect on blood pressure

Dutasteride

• Long half-life
• Sustained reduction in DHT
• Acts on hormonal cause of prostate enlargement

7. Dosage Form & Packaging

• Presented as a Strip of 10 Capsules.
• Designed for once-daily administration, as medically advised.

8. Purpose of the Combination

The combination addresses:

• Dynamic obstruction (muscle tension) → treated by Silodosin
• Static obstruction (enlarged prostate tissue) → treated by Dutasteride

This dual approach enhances overall urinary function and quality of life.