Description

RANCIL 5MG  STRIP OF 10 TABLET 

Composition: Each film-coated tablet contains Cilnidipine IP 5 mg, Excipients q.s.
Pack size: Strip of 10 tablets

Rancil 5 Tablet is a pharmaceutical preparation containing Cilnidipine 5 mg as its active ingredient. Cilnidipine is a modern antihypertensive drug belonging to the calcium channel blocker category, specifically a dihydropyridine derivative with dual L-type and N-type calcium channel blocking action.

The Rancil 5 tablet is designed for oral administration and is intended to help in the long-term management of high blood pressure (hypertension). The formulation ensures stable absorption, proper disintegration, and predictable therapeutic performance.

Rancil 5 is prepared using high-quality excipients that help maintain tablet stability, structural integrity, and shelf life. These excipients are present in quantity sufficient (q.s.) to support its function without affecting the therapeutic value of Cilnidipine.

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COMPOSITION DETAILS

Each film-coated tablet contains:

• Cilnidipine IP 5 mg

• Excipients q.s.

Excipients commonly include fillers, binders, lubricants, stabilizers, preservatives, and coating materials. These substances help in tablet formation, stability, and palatability.

 PHARMACEUTICAL FORM

• Dosage Form: Film-coated tablet

• Administration Route: Oral

• Pack Size: Strip of 10 tablets

The film coating protects the tablet from moisture, environmental factors, and handling damage. It also improves swallowing comfort and enhances appearance.

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DESCRIPTION OF ACTIVE INGREDIENT

Cilnidipine is a dual-action calcium channel blocker. Unlike traditional L-type blockers, Cilnidipine also inhibits N-type calcium channels, which reduces sympathetic nerve activity. This helps maintain smoother control of blood pressure throughout the day.

Key characteristics of Cilnidipine:

• Lipophilic nature

• Sustained activity

• Smooth onset of action

• Suitable for once-daily dosing

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 MECHANISM OF ACTION

L-type calcium channel blockade

• Reduces calcium entry into blood vessel walls

• Relaxes vascular smooth muscle

• Decreases peripheral resistance

• Lowers blood pressure

N-type calcium channel blockade

• Reduces release of norepinephrine from sympathetic nerve endings

• Minimizes stress-related blood pressure spikes

• Helps avoid reflex tachycardia

Because of this dual action, Cilnidipine provides more balanced blood pressure control.

 PHARMACOKINETICS

Absorption

Rancil 5 is well-absorbed through the gastrointestinal tract. Film coating ensures smooth passage.

Distribution

Cilnidipine is highly protein-bound and distributes consistently in tissues.

Metabolism

Metabolized primarily in the liver.

Excretion

Metabolites are excreted through urine and feces.

Half-Life

Supports once-daily administration.

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THERAPEUTIC USES

Rancil 5 (Cilnidipine 5 mg) is primarily used for:

• Management of mild to moderate hypertension

• Long-term blood pressure regulation

• Smooth and controlled reduction in systemic vascular resistance

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 BENEFITS OF CILNIDIPINE 5 MG

• Gentle and steady lowering of blood pressure

• Less swelling of feet compared to some other CCBs

• Dual L/N-type blocking mechanism

• Reduced sympathetic hyperactivity

• Better tolerance profile

• Consistent 24-hour coverage

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FORMULATION DETAILS

The formulation includes:

• Binders – to hold the tablet together

• Fillers – to add volume

• Disintegrants – to allow proper breakdown in stomach

• Lubricants – to prevent sticking during manufacturing

• Coating agents – for protection and stability

Each component is chosen to optimize the performance of the active ingredient.

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 PACKAGING INFORMATION

Rancil 5 is supplied in a strip of 10 tablets, each tablet individually sealed. Packaging ensures:

• Moisture protection

• UV protection

• Safe handling

• Portability

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 STORAGE CONDITIONS

Store in:

• A cool and dry place

• Temperature below 25°C

• Away from direct sunlight

• Out of reach of children

Keep tablets in original packaging until consumption.

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 PHYSICOCHEMICAL PROPERTIES

Cilnidipine is:

• Light-sensitive

• Moisture-sensitive

• Lipophilic in nature

• Stable under controlled storage

Film coating helps preserve these properties.

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CLINICAL EVIDENCE

Studies show that Cilnidipine:

• Provides smooth reduction of systolic and diastolic pressure

• Shows reduced incidence of leg swelling

• Offers better heart rate stability

• Gives improved cardiovascular comfort

• Is effective in long-term hypertension control

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POSSIBLE SIDE EFFECTS

(General information only – no advice)

• Headache

• Dizziness

• Warmth or flushing

• Mild swelling of feet

• Tiredness

• Mild stomach discomfort

Most effects are typically mild in nature.

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SAFETY & PRECAUTIONS

General considerations:

• Should be used as prescribed

• People with liver issues may require monitoring

• Alcohol may influence blood pressure

• Not to be crushed or broken unless advised

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TABLET HANDLING

• Swallow whole with water

• Do not chew

• Prefer taking at same time daily

• Keep strip sealed until dose is required

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OVERDOSAGE INFORMATION

General symptoms may include:

• Excessive drop in blood pressure

• Weakness

• Dizziness

Medical attention is recommended for such cases.

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DRUG INTERACTIONS

Possible interactions include:

• Other antihypertensive medicines

• Heart medications

• Certain neurological drugs

• Alcohol

• Herbal supplements

Interactions may modify blood pressure levels.

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ADVANTAGES OF FILM COATING

• Improves stability

• Protects from external factors

• Enhances visual appeal

• Aids in swallowing

• Helps maintain potency

• Cilnidipine 5 mg – Alternate Brand Price Table

  Brand Name (5 mg)	Pack Size	MRP / Offer Price	Approx Price per Tablet
  Rancil 5 (Sun Pharma)	Strip of 10	₹72.19 MRP / ₹61 Offer	~₹6.10 per tablet
  Cilipine 5	Strip of 10	₹31.31 Offer	~₹3.13 per tablet
  Cildip 5	Strip of 10	₹58.36 Offer	~₹5.84 per tablet
  Cinod 5	Strip of 20	₹129.75 Offer	~₹6.49 per tablet
  Dilnip 5	Strip of 15	₹102.34 Offer	~₹6.82 per tablet
  Cilnipres 5	Strip of 10	₹44.93 Offer	~₹4.49 per tablet
  Cetanil 5	Strip of 15	₹110.00 MRP (approx.)	~₹7.33 per tablet
  Cilacar 5	Strip of 15	₹160.00 MRP (approx.)	~₹10.66 per tablet
  Cilnicip 5	Strip of 10	₹45.00 MRP (approx.)	~₹4.50 per tablet
  Cilnigem 5	Strip of 10	₹40.00 MRP (approx.)	~₹4.00 per tablet
  Cilnistar 5	Strip of 10	₹55.00 MRP (approx.)	~₹5.50 per tablet
  Cilnipact 5	Strip of 10	₹52.00 MRP (approx.)	~₹5.20 per tablet
  Cilnizap 5	Strip of 10	₹48.00 MRP (approx.)	~₹4.80 per tablet
  Cilnigress 5	Strip of 10	₹60.00 MRP (approx.)	~₹6.00 per tablet
  Cilpower 5	Strip of 10	₹50.00 MRP (approx.)	~₹5.00 per tablet