Description

RANCIL 10mg – TABLET 

Rancil 10 Tablet is a pharmaceutical preparation that contains Cilnidipine IP 10 mg as its active ingredient. It is presented as a film-coated tablet, designed for oral administration. Cilnidipine belongs to the class of medications known as calcium channel blockers, more specifically a dual L-type and N-type calcium channel blocker. Because of this dual action, it is considered a modern and advanced molecule in the calcium channel blocker category.

Rancil 10 is commonly used in the management of high blood pressure (hypertension). By relaxing blood vessels and reducing pressure in the circulatory system, the medicine helps maintain stable and controlled blood pressure measurements. It is typically prescribed as part of long-term blood pressure management.

The formulation is manufactured with high standards of quality, ensuring stability, efficacy, and consistent therapeutic action. The tablet is crafted with excipients that help maintain its structural integrity, protection, and controlled release.

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2. COMPOSITION

Each film-coated Rancil 10 tablet contains:

• Cilnidipine IP 10 mg

• Excipients q.s. (quantity sufficient)

Excipients generally include ingredients used to form the tablet mass, aid disintegration, maintain stability, enhance appearance, and improve swallowing. These may include binders, fillers, coating agents, coloring agents, stabilizers, and lubricants.

The film coating protects the active ingredient from moisture, light, and handling damage, ensuring that the medicine reaches the gastrointestinal tract in optimal condition.

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3. APPEARANCE AND PACKAGING

Rancil 10 Tablets are presented in a strip pack of 10 tablets. The packaging is designed to ensure:

• Protection from environmental moisture

• Protection from light exposure

• Ease of transportation and handling

• Safe and hygienic storage

Each strip usually contains properly sealed blister pockets for individual tablets, reducing contamination and maintaining freshness until consumption.

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4. PHARMACOLOGICAL CLASSIFICATION

Cilnidipine is classified under:

• Calcium Channel Blockers (CCBs)

• Dihydropyridine class of CCBs

• Dual L/N-type calcium channel blocker

This dual action distinguishes Cilnidipine from other conventional CCBs such as amlodipine. Its additional action on N-type channels offers certain advantages related to sympathetic nerve inhibition.

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5. MECHANISM OF ACTION (DETAILED)

Cilnidipine works by blocking L-type calcium channels present in vascular smooth muscle cells. When these channels are blocked:

• Entry of calcium ions is reduced

• Vascular walls relax

• Peripheral resistance falls

• Blood pressure decreases

Cilnidipine also blocks N-type calcium channels situated in sympathetic nerve endings. Blocking these channels leads to:

• Reduced release of norepinephrine

• Lower sympathetic nerve activity

• Reduction in stress-related increases in blood pressure

This unique dual-channel blocking mechanism helps in maintaining smoother control of blood pressure.

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6. PHARMACOKINETICS

Absorption

Cilnidipine is well absorbed after oral administration. The film coating helps the drug pass smoothly through the gastrointestinal tract.

Distribution

Once absorbed, the medicine binds extensively to plasma proteins, allowing consistent action over a prolonged period.

Metabolism

Cilnidipine undergoes hepatic metabolism through enzymatic activity in the liver.

Excretion

Metabolites are eliminated predominantly through urine and fecal matter, ensuring gradual clearance.

Half-life

Cilnidipine has a duration that supports once-daily dosing in most clinical situations.

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7. THERAPEUTIC USES

Rancil 10 (Cilnidipine 10 mg) is mainly used for the management of hypertension. It helps:

• Maintain stable blood pressure levels

• Prevent fluctuations caused by stress

• Reduce peripheral vascular resistance

Consistent blood pressure control helps reduce long-term risks associated with hypertension.

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8. BENEFITS OF CILNIDIPINE

Cilnidipine offers several benefits over traditional calcium channel blockers:

A. Dual L/N-type blockade

Provides a more balanced blood pressure-lowering effect.

B. Smooth reduction of BP

Helps avoid sudden drops in blood pressure.

C. Reduced reflex tachycardia

Because of its N-type channel action, compensatory heart rate increase is minimized.

D. Improved vascular health

Helps maintain relaxed and healthy blood vessels.

E. Long duration of action

Suitable for once-daily usage.

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9. TABLET FORMULATION DETAILS

The tablet contains:

• Active ingredient: Cilnidipine

• Fillers: Provide mass to the tablet

• Binders: Hold the tablet together

• Disintegrants: Allow the tablet to break down properly

• Lubricants: Prevent sticking to machinery

• Coating materials: Protect against moisture/light

The manufacturing process includes mixing, granulation, compression, and final film coating.

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10. STORAGE CONDITIONS

Rancil 10 should be stored:

• Below room temperature (usually below 25°C)

• Away from direct sunlight

• In a dry location

• Out of reach of children

The blister packaging should not be pierced or opened until use.

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11. QUALITY AND SAFETY STANDARDS

Rancil 10 is manufactured according to pharmaceutical standards that include:

• Good Manufacturing Practices (GMP)

• Quality testing for purity

• Stability testing

• Uniformity of dosage

• Safety assessments

Each batch undergoes stringent quality control to ensure accuracy of dosage and safety.

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12. CLINICAL DATA AND EFFECTIVENESS

Clinical studies have shown that Cilnidipine:

• Effectively lowers systolic and diastolic blood pressure

• Provides consistent 24-hour control

• Has a smooth onset of action

• Has better tolerability in some patients compared to older drugs

• Supports long-term therapy with stable results

Its dual mechanism contributes to improved cardiovascular comfort.

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13. POSSIBLE SIDE EFFECTS

Side effects vary from person to person. Some commonly reported ones include:

• Mild headache

• Dizziness

• Flushing

• Slight swelling in legs or ankles

• Warm sensation

• Fatigue

These are generally mild in nature and often reduce with continued use.

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14. PRECAUTIONS

Before starting Cilnidipine therapy:

• History of liver problems should be considered

• Alcohol consumption may influence blood pressure

• Elderly patients may require cautious monitoring

The medicine should be taken exactly as prescribed.

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15. SUITABILITY AND PATIENT TYPE

Rancil 10 is typically suitable for:

• Adults with primary hypertension

• Patients requiring long-term BP control

• Individuals needing smoother, balanced BP reduction

It is generally not used in acute hypertensive emergencies.

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16. MODE OF ADMINISTRATION

• Taken orally

• Swallowed whole with water

• Not to be chewed or crushed

• Usually taken once daily

• Preferably at the same time every day

The tablet’s film coating helps smooth ingestion and controlled release.

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17. OVERDOSAGE INFORMATION

Excessive intake may lead to:

• Excessive drop in blood pressure

• Dizziness

• Weakness

Immediate medical attention is recommended in such cases.

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18. DRUG INTERACTIONS

Rancil 10 may interact with:

• Other antihypertensives

• Certain heart medications

• Some neurological drugs

• Alcohol

• Herbal supplements

These interactions may influence blood pressure levels.

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19. ADVANTAGES OF FILM COATING

The protective film coating provides:

• Moisture resistance

• Easy swallowing

• Improved stability

• Protection from mechanical damage

It also enhances appearance and surface smoothness.

Rancil 10 is a modern, effective, and well-designed tablet containing Cilnidipine 10 mg, used primarily for the long-term management of hypertension. With its dual L/N-type calcium channel blocking action, it provides smoother and more balanced blood pressure control. The tablet is manufactured with high-quality excipients and strict standards to ensure reliable performance.

It remains a trusted choice in the antihypertensive category due to its stability, advanced mechanism, tolerability, and long-term effectiveness.