Description

Pulmocef-250 – Strip of 10 Tablets

Cefuroxime Axetil 250 mg

Pulmocef-250 is a broad-spectrum oral antibiotic belonging to the second-generation cephalosporin group. It is widely prescribed for the treatment of bacterial infections affecting the respiratory tract, urinary tract, ear, nose and throat, skin, and soft tissues. The medicine is intended for use only under medical supervision.

Composition

Each film-coated tablet contains Cefuroxime Axetil IP equivalent to Cefuroxime 250 mg.
Other inactive ingredients are present in suitable quantities to maintain tablet stability and absorption.

Description

Cefuroxime Axetil is a prodrug that is converted in the body into its active form, Cefuroxime. After oral administration, it is absorbed from the gastrointestinal tract and rapidly hydrolysed to the active antibiotic. Pulmocef-250 is effective against a wide range of Gram-positive and Gram-negative bacteria.

Pharmacological Class

Pulmocef-250 belongs to the beta-lactam class of antibiotics and is categorised as a second-generation cephalosporin. It exhibits bactericidal activity.

Mechanism of Action

Cefuroxime works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins present in the bacterial cell membrane, preventing the formation of a strong and protective cell wall. This leads to weakening of the bacterial structure, cell rupture, and eventual death of the bacteria.

Antibacterial Spectrum

Pulmocef-250 is active against many common pathogens including Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus (non-MRSA strains), Haemophilus influenzae, Escherichia coli, Klebsiella species, Proteus mirabilis, Moraxella catarrhalis, and Neisseria gonorrhoeae. It is not effective against MRSA, Pseudomonas aeruginosa, or Enterococcus species.

Pharmacokinetics

After oral administration, absorption is enhanced when the tablet is taken with food. The drug is widely distributed in body tissues including lungs, sinuses, tonsils, skin, urinary tract, and bones. Cefuroxime is primarily eliminated through the kidneys in unchanged form. The average half-life is approximately one to one and a half hours in individuals with normal renal function.

Therapeutic Indications

Pulmocef-250 is used in the treatment of respiratory tract infections such as bronchitis and pneumonia, ear and throat infections including tonsillitis and otitis media, sinusitis, urinary tract infections, skin and soft tissue infections, bone and joint infections, and certain sexually transmitted infections when prescribed by a physician.

Dosage and Administration

The usual adult dose is 250 mg taken twice daily. In more severe infections, the dose may be increased as directed by the physician. The duration of treatment generally ranges from seven to ten days depending on the severity of infection and clinical response. The tablet should be swallowed whole with water and taken after food for better absorption.

Use in Special Populations

In patients with kidney impairment, dose adjustment may be required. Elderly patients should be monitored for renal function. Use during pregnancy should be based on medical advice, and caution is advised during breastfeeding as small amounts of the drug may pass into breast milk.

Contraindications

Pulmocef-250 should not be used in patients with known hypersensitivity to cefuroxime, other cephalosporins, or beta-lactam antibiotics. It is also contraindicated in individuals with a history of severe allergic reactions to penicillins.

Warnings and Precautions

Caution is advised in patients with a history of gastrointestinal disorders, particularly colitis. Prolonged use may result in secondary infections. Allergic reactions, including severe skin reactions, may occur and require immediate medical attention. Renal function should be monitored during long-term therapy.

Drug Interactions

Pulmocef-250 may interact with medicines such as probenecid, anticoagulants, oral contraceptives, nephrotoxic drugs, and live bacterial vaccines. Patients should inform their doctor about all medicines they are taking.

Side Effects

Common side effects include nausea, vomiting, diarrhoea, abdominal discomfort, headache, and dizziness. Less common effects include skin rash, itching, and fungal infections. Rare but serious adverse reactions include severe allergic reactions, antibiotic-associated colitis, blood disorders, and serious skin conditions.

Overdose

Overdose symptoms may include severe gastrointestinal disturbances and, in rare cases, seizures. Immediate medical attention is required, and treatment is supportive.

Laboratory Test Interference

Pulmocef-250 may interfere with certain urine glucose tests and Coombs tests.

Storage

Store in a cool, dry place below 25°C. Protect from light and moisture. Keep out of reach of children.

Patient Counseling Information

Patients should complete the full prescribed course even if symptoms improve. The medicine should not be shared with others. Any signs of allergy or persistent diarrhoea should be reported to a healthcare professional immediately.

Pulmocef-250 is a well-established oral antibiotic with broad-spectrum activity and good tolerability. When used appropriately under medical supervision, it provides effective treatment for a variety of bacterial infections.

Pulmocef-250 – Alternate Brands

Composition: Cefuroxime Axetil 250 mg
Pack: Strip of 10 Tablets

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