Description

Prostagard-D 8 – strip of 10 tablets

Prostagard-D 8 is a combination capsule formulated for the treatment of Benign Prostatic Hyperplasia (BPH), a non-cancerous enlargement of the prostate gland that commonly affects aging men. This dual-therapy capsule helps relieve urinary symptoms and also targets the hormonal cause of prostate enlargement.

2. Composition

Each hard gelatin capsule contains:

• Silodosin 8 mg (as granules)

• Dutasteride IP 0.5 mg

• Excipients q.s.

3. Nature of Ingredients

Silodosin (8 mg)

A highly selective alpha-1A adrenergic receptor blocker that relaxes smooth muscles of the prostate, bladder base, and urethra.

Dutasteride (0.5 mg)

A potent 5-alpha reductase inhibitor that reduces the production of dihydrotestosterone (DHT), the hormone responsible for prostate gland enlargement.

4. Mechanism of Action

Silodosin

• Selectively blocks alpha-1A receptors located primarily in the prostate and bladder neck.

• Relaxes smooth muscles, helping reduce urinary obstruction.

• Improves urine flow, reduces hesitancy, alleviates straining, and enhances bladder emptying.

Dutasteride

• Inhibits both Type-1 and Type-2 5-alpha reductase enzymes.

• Lowers DHT levels significantly within the prostate.

• Gradually reduces prostate volume and slows the progression of BPH.

• Decreases the risk of acute urinary retention.

5. Indications

Prostagard-D 8 is used for the management of Benign Prostatic Hyperplasia (BPH) symptoms such as:

• Weak urinary stream

• Frequent urination

• Nocturia (night-time urination)

• Dribbling of urine

• Difficulty initiating urination

• Sensation of incomplete bladder emptying

• Urinary urgency

6. Therapeutic Benefits

• Provides fast symptomatic relief due to Silodosin.

• Offers long-term improvement through prostate size reduction by Dutasteride.

• Improves urinary flow rate and reduces lower urinary tract symptoms.

• Helps stabilize bladder pressure and decreases urinary frequency.

• Lowers chances of urinary retention and reduces possible need for surgery.

• Addresses both muscular tension and gland enlargement for complete management.

7. Pharmacological Characteristics

Silodosin

• Rapid onset of action

• Highly selective receptor blocking

• Minimal effect on systemic blood pressure

Dutasteride

• Long half-life ensuring sustained hormone suppression

• Effective in reducing prostate volume over extended use

8. Dosage Form & Packaging

• Supplied as a Strip of 10 Hard Gelatin Capsules.

• Designed for once-daily administration as clinically directed.

9. Purpose of the Combination

The combination of Silodosin and Dutasteride targets both components of BPH:

• Dynamic Obstruction – caused by muscle tension in the bladder neck and prostate (managed by Silodosin)

• Static Obstruction – caused by enlarged prostate tissue (managed by Dutasteride)