Pan-D Capsule PR is another combination medication containing Domperidone (30mg) and Pantoprazole (40mg). This formulation appears to be a Prolonged Release (PR) version, indicating that the drug is designed to be released gradually over time, offering a more sustained effect and potentially fewer doses compared to standard formulations.

Active Ingredients:

1. Domperidone (30mg):
   • Class: Anti-nausea and prokinetic agent.
   • Action: Domperidone acts on the dopamine receptors in the gut to increase gastric motility, which helps prevent nausea and vomiting. It also aids in moving food through the digestive system more efficiently.
   • Higher dosage (30mg): The 30mg dose is relatively higher compared to the usual 10mg or 20mg doses in other formulations, which may indicate its use in more severe cases of nausea, vomiting, or gastric motility disorders.
2. Pantoprazole (40mg):
   • Class: Proton pump inhibitor (PPI).
   • Action: Pantoprazole reduces stomach acid production by inhibiting the proton pump in the stomach lining, which helps treat acid reflux, ulcers, and other conditions related to excess stomach acid.
   • Higher dosage (40mg): The 40mg dose of pantoprazole is often used in patients with more severe acid-related conditions such as severe GERD or peptic ulcers.

Indications:

Pan-D Capsule PR is generally prescribed for:

• Gastroesophageal reflux disease (GERD)
• Acid reflux or heartburn
• Peptic ulcers
• Functional dyspepsia
• Helicobacter pylori eradication (in combination with antibiotics)
• Gastroparesis (delayed gastric emptying)
• Nausea and vomiting associated with digestive disorders

Key Features of the PR (Prolonged Release) Formulation:

• Sustained Action: The prolonged-release (PR) formulation ensures that the active ingredients are released slowly over time. This leads to a longer-lasting effect, reducing the need for frequent dosing.
• Once Daily: Usually, sustained-release forms like Pan-D PR are taken once daily, providing a more convenient treatment schedule for patients.

Dosage:

• Typical Dose: The exact dosage should be prescribed by your doctor. Since this is a prolonged-release formulation, it is typically taken once a day, but your doctor will adjust it according to your condition.
• Timing: Pan-D PR should be taken before meals, usually 30 minutes prior to eating, as this helps optimize the effectiveness of both the pantoprazole and domperidone.

Common Side Effects:

• Headache
• Diarrhea or constipation
• Abdominal discomfort
• Dry mouth or dizziness
• Fatigue or weakness
• Increased risk of infections (with prolonged use of pantoprazole)

Precautions:

• Liver or kidney issues: If you have any liver or kidney problems, your doctor may need to adjust your dosage.
• Prolonged use of PPIs: Long-term use of pantoprazole has been associated with certain risks, such as low magnesium levels, osteoporosis, or vitamin B12 deficiency.
• Pregnancy and breastfeeding: If you are pregnant or breastfeeding, consult your doctor before using this medication.
• Drug Interactions: Both domperidone and pantoprazole can interact with other medications, so it’s important to inform your doctor about any other medications you are taking.

Storage:

• Store below 30°C: Keep the capsules in a cool, dry place, away from direct sunlight or moisture, to maintain their effectiveness.

Important Notes:

• Prescription Required: This is a prescription-only medication, so you must use it under the guidance of a healthcare provider.
• Do not crush or chew: As this is a sustained-release formulation, it should not be crushed or chewed. Swallow the capsule whole for proper absorption.