Description

Nexpro Rd 20 – Strip of 10 Capsules

Nexpro RD 20 is a combination medication containing Esomeprazole and Domperidone, designed to treat conditions involving both acid reflux and impaired gastric motility. Here’s a detailed overview:

Composition:

• Esomeprazole 20 mg
• Domperidone 10 mg
• Form: Capsules (10 capsules per strip)

About the Components:

1. Esomeprazole (20 mg):
   Esomeprazole is a proton pump inhibitor (PPI) that reduces stomach acid production by blocking the proton pumps in the stomach lining. It is commonly used to treat acid-related conditions like GERD (gastroesophageal reflux disease), peptic ulcers, and gastritis.
2. Domperidone (10 mg):
   Domperidone is a prokinetic agent, which means it helps increase the movement of the stomach and intestines. It works by enhancing gastric motility, which aids in quicker gastric emptying and reduces symptoms such as nausea, vomiting, and bloating. Domperidone is often used for gastroparesis, a condition where the stomach empties too slowly.

Common Uses of Nexpro RD 20:

This combination is used to treat conditions involving both acid reflux and impaired gastric motility, such as:

• Gastroesophageal reflux disease (GERD): By reducing stomach acid production (Esomeprazole) and improving gastric motility (Domperidone), this medication helps manage GERD symptoms like heartburn, regurgitation, and acid reflux.
• Gastroparesis: A condition in which the stomach empties too slowly, causing symptoms like nausea, bloating, and feeling full.
• Indigestion (Dyspepsia): To relieve symptoms of indigestion, which may include bloating, discomfort, and nausea.
• Nausea and vomiting: Domperidone helps control nausea and vomiting caused by various digestive issues.

How It Works:

• Esomeprazole reduces the production of stomach acid by blocking proton pumps in the stomach lining.
• Domperidone enhances the motility of the stomach and intestines, helping food move more efficiently through the digestive tract and reducing symptoms like nausea, bloating, and slow gastric emptying.

Dosage:

• Typical Dosage: The usual dose is 1 capsule once daily, or as prescribed by a doctor. The specific dosage may vary depending on the condition being treated and the individual’s response to the medication.
• Administration: Nexpro RD 20 capsules should be swallowed whole with a glass of water, usually before meals. They should not be chewed or crushed.

Possible Side Effects:

• Common side effects:
  • Headache
  • Nausea
  • Abdominal pain or discomfort
  • Dry mouth
  • Diarrhea or constipation
• Serious side effects (rare but possible):
  • Extrapyramidal symptoms (movement disorders): These can include symptoms like tremors, muscle spasms, or rigidity, especially in the elderly.
  • Cardiac arrhythmias (irregular heartbeats): This is particularly a concern with Domperidone, especially if there is a pre-existing heart condition.
  • Kidney or liver problems: Prolonged use of Esomeprazole may affect kidney and liver function, so monitoring may be necessary in patients with pre-existing conditions.

Precautions:

• Cardiac Health: Since Domperidone may cause heart rhythm problems (arrhythmias), caution is required for those with heart conditions or taking other medications that affect heart rhythm.
• Kidney and liver function: Esomeprazole and Domperidone should be used with caution in patients with liver or kidney issues. Dosage adjustments may be necessary.
• Pregnancy and breastfeeding: Always consult a healthcare provider before using Nexpro RD 20 during pregnancy or breastfeeding.

Drug Interactions:

• Esomeprazole may interact with medications such as warfarin (a blood thinner), ketoconazole (antifungal), and clopidogrel (blood thinner), among others.
• Domperidone may interact with anticholinergics, antipsychotic medications, and certain other drugs that affect the nervous system.

Warnings:

• Movement disorders: Long-term use of Domperidone can lead to movement-related side effects (e.g., tremors, muscle spasms), particularly in elderly individuals.
• Heart issues: If you have a history of heart disease, caution is advised due to the potential for cardiac arrhythmias from Domperidone.