Description

Nexpro L – Strip of 10 Capsules

Nexpro L is a medication that combines Esomeprazole and Levosulpiride. Here’s a detailed overview:

Composition:

• Esomeprazole 40 mg
• Levosulpiride 25 mg
• Form: Capsules (10 capsules per strip)

About the Components:

1. Esomeprazole (40 mg):
   Esomeprazole is a proton pump inhibitor (PPI) that reduces stomach acid production by blocking the proton pumps in the stomach lining. This helps to treat conditions like GERD, peptic ulcers, and other acid-related gastrointestinal disorders.
2. Levosulpiride (25 mg):
   Levosulpiride is a prokinetic agent. It works by stimulating the movement of the stomach and intestines, promoting gastric motility and aiding in the quicker emptying of the stomach. It is used to treat gastroparesis, indigestion, and nausea.

Common Uses of Nexpro L:

This combination of Esomeprazole and Levosulpiride is used to treat conditions involving both acid reflux and impaired gastric motility. Common indications include:

• Gastroesophageal reflux disease (GERD): This medication helps by reducing stomach acid production (Esomeprazole) and improving gastric motility (Levosulpiride), both of which help reduce the symptoms of acid reflux.
• Indigestion or dyspepsia: For conditions where delayed gastric emptying causes discomfort, bloating, and nausea.
• Gastroparesis: A condition where the stomach empties too slowly, causing nausea, vomiting, and bloating.
• Nausea and vomiting: Levosulpiride aids in reducing nausea by improving the stomach’s motility.

How It Works:

• Esomeprazole works by blocking proton pumps in the stomach lining, reducing acid production.
• Levosulpiride works as a prokinetic agent, improving gastric motility and aiding in quicker gastric emptying, helping to alleviate symptoms like nausea and indigestion.

Dosage:

• Typical Dosage: Usually, 1 capsule of Nexpro L is taken once daily or as prescribed by the doctor. The exact dosage depends on the severity of the condition being treated.
• Administration: It should be taken as directed, usually before meals, and swallowed whole with a glass of water.

Possible Side Effects:

• Common side effects may include:
  • Headache
  • Diarrhea or constipation
  • Abdominal discomfort
  • Nausea
  • Dizziness
• Serious side effects (rare but serious):
  • Extrapyramidal symptoms (e.g., muscle spasms, tremors) due to Levosulpiride, especially with long-term use or in elderly individuals.
  • Kidney or liver problems (particularly with prolonged use of Esomeprazole)
  • Cardiac arrhythmias (irregular heartbeats, rare but possible with Levosulpiride)

Precautions:

• Prolonged use: Long-term use of PPIs like Esomeprazole may increase the risk of bone fractures, magnesium deficiency, and vitamin B12 deficiency.
• Levosulpiride: Caution should be used if the patient has a history of movement disorders or heart problems.
• Pregnancy and breastfeeding: It is important to consult with a healthcare provider before using Nexpro L during pregnancy or breastfeeding.
• Kidney and liver function: Both components may require dose adjustments in patients with impaired kidney or liver function.

Drug Interactions:

• Esomeprazole may interact with drugs that alter stomach acid, such as antacids or antifungals, as well as drugs like clopidogrel (a blood thinner) or methotrexate.
• Levosulpiride may interact with antipsychotic drugs, antidepressants, or other medications that affect the nervous system.

Warnings:

• Cardiac Health: Due to the potential for cardiac arrhythmias with Levosulpiride, caution should be taken, especially in patients with heart disease.
• Nervous System Effects: Levosulpiride, as an antipsychotic drug, can sometimes cause movement-related side effects (like tremors) in susceptible individuals, particularly when used long-term.