Minoz ER 65 Tablet

Description

Minoz ER 65 Tablet

Composition

Each film-coated extended-release tablet contains:

• Minocycline Hydrochloride USP, equivalent to Minocycline 65 mg

• Excipients: q.s.

• Colours: Ferric Oxide (Yellow) USP-NF, Titanium Dioxide IP

Dosage Form and Pharmaceutical Class

Minoz ER 65 is an oral extended-release tablet belonging to the tetracycline group of antibiotics. The extended-release formulation allows gradual release of minocycline over time, helping maintain stable drug levels in the body.

Minoz ER 65 tablets are film-coated to aid swallowing and protect the extended-release core. The colour coating is derived from approved pharmaceutical colouring agents. The formulation is designed for once-daily administration unless otherwise directed by a physician.

Mechanism of Action

Minocycline acts by binding to the 30S ribosomal subunit of susceptible bacteria. This action inhibits bacterial protein synthesis, thereby preventing bacterial growth and multiplication. The drug is bacteriostatic in nature and relies on the immune system to clear the infection.

Pharmacological Properties

Minocycline is well absorbed from the gastrointestinal tract. The extended-release formulation reduces fluctuations in plasma concentration, which may help improve tolerability and adherence. The drug distributes widely into body tissues, including skin and respiratory tissues. It undergoes partial hepatic metabolism and is eliminated through both renal and fecal routes. The relatively long half-life supports once-daily dosing.

Therapeutic Indications

Minoz ER 65 is used in the treatment of bacterial infections caused by susceptible organisms. It is commonly prescribed for:

• Moderate to severe acne vulgaris

• Skin and soft tissue infections

• Respiratory tract infections

• Certain urinary tract infections

• Other bacterial infections as determined by clinical judgment

It is effective only against bacterial infections and does not treat viral illnesses.

Dosage and Administration

The dosage and duration of therapy are determined by the physician based on the patient’s condition, age, and response to treatment. The tablet should be swallowed whole with a full glass of water. It should not be crushed, chewed, or broken, as this may interfere with the extended-release mechanism. The tablet may be taken with or without food, preferably at the same time each day.

Contraindications

Minoz ER 65 is contraindicated in patients with known hypersensitivity to minocycline or other tetracyclines. It should not be used in children under 8 years of age due to the risk of permanent tooth discoloration and effects on bone growth. Use is contraindicated during pregnancy and generally avoided during breastfeeding unless clearly advised by a physician.

Warnings and Precautions

Caution is advised in patients with liver or kidney impairment. Prolonged use may require periodic monitoring of liver and renal function. Increased sensitivity to sunlight may occur, and protective measures against sun exposure are recommended. Dizziness or light-headedness may occur; patients should use caution while driving or operating machinery.

Adverse Effects

Commonly reported side effects include nausea, vomiting, diarrhea, headache, dizziness, and gastrointestinal discomfort. Skin rash and photosensitivity reactions may occur. Rare but serious adverse effects include severe allergic reactions, liver dysfunction, vestibular disturbances, and intracranial hypertension. Any severe or persistent adverse effects should be reported to a healthcare provider immediately.

Drug Interactions

Absorption of minocycline may be reduced when taken simultaneously with antacids, calcium, iron, magnesium, or zinc supplements. A time gap is recommended between such products and Minoz ER 65. Concomitant use with oral contraceptives may reduce contraceptive effectiveness. Caution is advised when used with retinoids or anticoagulants.

Use in Special Populations

Use during pregnancy is not recommended due to potential effects on fetal bone and tooth development. Breastfeeding mothers should consult a physician before use. Pediatric use is restricted due to effects on developing teeth and bones. Elderly patients may be more susceptible to dizziness and organ-related side effects.

Overdose

Symptoms of overdose may include nausea, vomiting, dizziness, or gastrointestinal irritation. In case of suspected overdose, medical attention should be sought immediately.

Missed Dose

If a dose is missed, it should be taken as soon as remembered unless it is nearly time for the next scheduled dose. Double dosing should be avoided.

Storage

Store in a cool, dry place away from direct sunlight and moisture. Keep out of reach of children.

Patient Counseling Information

Patients should be advised to complete the full prescribed course even if symptoms improve earlier. They should avoid lying down immediately after taking the tablet and should use sun protection during treatment. Any unusual symptoms should be promptly reported to a healthcare professional.