Minoz ER 45 Tablet-10′

Minoz ER 45 Tablet

Composition

Each film-coated extended-release tablet contains:

• Minocycline Hydrochloride USP, equivalent to Minocycline 45 mg

• Excipients: q.s.

Dosage Form and Pharmaceutical Class

Minoz ER 45 is an oral extended-release tablet belonging to the tetracycline class of antibiotics. The extended-release formulation allows gradual release of minocycline over an extended period, helping maintain steady blood concentrations and improving tolerability.

Description

Minoz ER 45 tablets are film-coated for ease of swallowing and protection of the extended-release core. This lower-strength ER formulation is commonly used for acne management and situations where a reduced daily dose is clinically appropriate.

Mechanism of Action

Minocycline exerts its antibacterial effect by binding to the 30S ribosomal subunit of susceptible bacteria. This inhibits bacterial protein synthesis, preventing bacterial growth and multiplication. The action is bacteriostatic, meaning it suppresses bacterial growth rather than directly killing bacteria.

Pharmacological Properties

Minocycline is well absorbed following oral administration. The extended-release design reduces peak plasma concentrations and maintains sustained drug levels throughout the day. The drug distributes widely into tissues, particularly skin and soft tissues. It undergoes partial hepatic metabolism and is eliminated through both renal and fecal pathways. The pharmacokinetic profile supports once-daily dosing.

Therapeutic Indications

Minoz ER 45 is indicated for the treatment of bacterial infections caused by organisms sensitive to minocycline. It is commonly prescribed for:

• Mild to moderate acne vulgaris

• Skin and soft tissue infections

• Respiratory tract infections

• Other susceptible bacterial infections as determined by the physician

It is not effective against viral infections.

Dosage and Administration

Dosage and duration of treatment are determined by the physician based on the patient’s condition and clinical response. The tablet should be swallowed whole with a full glass of water. It must not be crushed, chewed, or broken, as this can interfere with the extended-release mechanism. The tablet may be taken with or without food and should ideally be taken at the same time each day.

Contraindications

Minoz ER 45 is contraindicated in patients with known hypersensitivity to minocycline or other tetracyclines. It should not be used in children under 8 years of age due to the risk of permanent tooth discoloration and effects on bone development. Use during pregnancy is contraindicated, and use during breastfeeding should be avoided unless specifically advised by a healthcare professional.

Warnings and Precautions

Caution is advised in patients with liver or kidney impairment. Prolonged use may require monitoring of liver and renal function. Increased sensitivity to sunlight may occur; patients should minimize sun exposure and use protective measures. Dizziness or light-headedness may occur, and caution is advised when driving or operating machinery.

Adverse Effects

Common adverse effects include nausea, vomiting, diarrhea, abdominal discomfort, headache, and dizziness. Skin rash and photosensitivity reactions may occur. Rare but serious adverse effects include severe allergic reactions, liver dysfunction, vestibular disturbances, and increased intracranial pressure.

Drug Interactions

Absorption of minocycline may be reduced when taken with antacids or supplements containing calcium, iron, magnesium, or zinc; a sufficient time gap should be maintained. Concomitant use with oral contraceptives may reduce contraceptive effectiveness. Caution is advised when used with retinoids or anticoagulants.

Use in Special Populations

Use during pregnancy is not recommended due to potential risks to fetal bone and tooth development. Breastfeeding mothers should consult a healthcare professional before use. Pediatric use is restricted. Elderly patients may be more susceptible to dizziness and organ-related adverse effects.

Overdose

Symptoms of overdose may include nausea, vomiting, dizziness, or gastrointestinal irritation. Medical attention should be sought immediately in cases of suspected overdose.

Missed Dose

If a dose is missed, it should be taken as soon as remembered unless it is nearly time for the next dose. Double dosing should be avoided.

Storage

Store in a cool, dry place away from heat, moisture, and direct sunlight. Keep out of reach of children.

Patient Counseling Information

Patients should be advised to complete the full prescribed course even if symptoms improve. Avoid lying down immediately after taking the tablet. Use adequate sun protection during therapy. Any severe or unusual symptoms should be reported promptly to a healthcare provider.

Minoz ER 45 is a lower-strength extended-release formulation of minocycline designed for effective and convenient treatment of bacterial infections, particularly acne, with once-daily dosing and a well-established safety profile when used under medical supervision.