Midodrive 2.5 mg Tablet-10′

Description

Midodrive 2.5 mg Tablet

Composition

Each tablet contains:

• Midodrine Hydrochloride, equivalent to Midodrine 2.5 mg

• Excipients: q.s.

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Dosage Form and Pharmaceutical Class

Midodrive 2.5 mg is an oral tablet belonging to the class of alpha-1 adrenergic agonists. It is primarily used to increase blood pressure in patients with symptomatic orthostatic hypotension.

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Description

Midodrive tablets are designed for oral administration and provide a low-dose formulation (2.5 mg) suitable for titration in patients sensitive to blood pressure changes. The tablets are intended for systemic absorption, with predictable pharmacodynamic effects on vascular tone.

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Mechanism of Action

Midodrine is a prodrug that is metabolized into desglymidodrine, an active metabolite. It stimulates alpha-1 adrenergic receptors in blood vessels, causing vasoconstriction. This increases peripheral vascular resistance and raises blood pressure, particularly when standing, thereby reducing symptoms of dizziness or fainting in orthostatic hypotension.

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Pharmacological Properties

• Absorption: Rapidly absorbed from the gastrointestinal tract.

• Metabolism: Converted to active metabolite desglymidodrine by liver and kidney enzymes.

• Elimination: Excreted primarily in urine.

• Onset of Action: Typically within 30–60 minutes after oral dosing.

• Duration of Effect: 2–4 hours per dose.

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Therapeutic Indications

Midodrive 2.5 mg tablets are used for:

• Symptomatic orthostatic hypotension caused by conditions such as:

  • Autonomic dysfunction

  • Neurodegenerative disorders (e.g., Parkinson’s disease)

  • Other causes of chronic low blood pressure

• Helps reduce dizziness, lightheadedness, and fainting episodes associated with low standing blood pressure.

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Dosage and Administration

• Dosage must be individualized based on blood pressure response and symptom control.

• Tablets are usually taken 2–3 times daily, with at least 4 hours between doses.

• Avoid bedtime dosing to prevent supine hypertension.

• Swallow the tablet whole with water; may be taken with or without food.

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Contraindications

• Known hypersensitivity to midodrine or any component of the formulation.

• Severe organic heart disease, acute renal disease, or thyrotoxicosis may require caution.

• Patients with supine hypertension should not take the medication at bedtime.

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Warnings and Precautions

• Monitor blood pressure: Supine hypertension can occur, especially with evening doses.

• Renal impairment: Dose adjustment may be necessary.

• Pregnancy and breastfeeding: Use only if clearly needed and prescribed by a physician.

• Caution in elderly patients: Increased risk of supine hypertension or cardiovascular side effects.

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Adverse Effects

Common adverse effects may include:

• Paresthesia (tingling sensation)

• Goosebumps or chills

• Piloerection (hair standing on end)

• Urinary retention or difficulty urinating

• Supine hypertension (high blood pressure while lying down)

• Headache

• Itching or rash

Less common but serious effects include chest pain, palpitations, or severe hypertension, which require immediate medical attention.

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Drug Interactions

• Antihypertensives: May counteract blood pressure-lowering medications.

• Vasoconstrictors or sympathomimetics: May potentiate hypertensive effects.

• MAO inhibitors or other adrenergic agents: Monitor closely to avoid excessive blood pressure elevation.

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Use in Special Populations

• Pregnancy: Only if clearly necessary.

• Breastfeeding: Consult physician; limited data on excretion in milk.

• Pediatric Use: Safety and efficacy in children not well established; use only if prescribed.

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Overdose

Symptoms may include severe hypertension, headache, and bradycardia. Seek immediate medical attention if overdose is suspected. Treatment is supportive, including monitoring blood pressure and cardiovascular function.

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Missed Dose

Take the missed dose as soon as remembered if it is not near the next scheduled dose. Do not double the dose. Avoid taking doses close to bedtime.

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Storage

Store in a cool, dry place away from sunlight, moisture, and heat. Keep out of reach of children.

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Patient Counseling Information

• Take the medication exactly as prescribed.

• Monitor blood pressure, especially when lying down.

• Avoid taking the tablet just before sleep to reduce risk of supine hypertension.

• Report any chest pain, palpitations, or severe headache promptly.

• Alternate Brands – Midodrine 2.5 mg Tablets (with MRPs)

  Brand Name	Pack Size	Approx. MRP / Price (₹)	Notes
  Midotab 2.5 mg Tablet 20’s	20 tablets	~784.80	Generic formulation; commonly stocked
  Midorise 2.5 mg Tablet 20’s	20 tablets	~972	Branded generic by first‑line manufacturer
  Midodrive 2.5 mg Tablet 20’s	20 tablets	~1,011.65	Established branded option
  Midora 2.5 mg Tablet 30’s	30 tablets	~2,593.80	Higher pack size by large manufacturer

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