Description
Halovate Cream – 30g Tube
📦 Composition (per gram):
| Ingredient | Strength | Purpose |
|---|---|---|
| Halobetasol Propionate USP | 0.05% w/w | Super-potent topical corticosteroid |
| Methyl Paraben I.P. | 0.2% w/w | Preservative (antimicrobial, antifungal) |
| Propyl Paraben I.P. | 0.02% w/w | Preservative (enhances stability & shelf life) |
| Cream Base | q.s. | Carrier base for smooth application |
🧪 Halobetasol is approximately 600 times more potent than hydrocortisone and significantly stronger than Betamethasone or Clobetasol.
🎯 Indications / Therapeutic Uses:
Halovate is reserved for severe, resistant, and steroid-responsive dermatoses, such as:
| Condition | Notes |
|---|---|
| Psoriasis (plaque-type) | Especially resistant or thick plaques |
| Eczema (chronic, lichenified) | Where lower-potency steroids fail |
| Lichen planus | Reduces inflammation & pruritus |
| Discoid lupus erythematosus | Topical management of limited lesions |
| Severe contact/atopic dermatitis | Under strict medical guidance |
| Seborrheic dermatitis (localized) | Short-term, very limited use |
| Other steroid-responsive dermatoses | Under dermatologist supervision |
⚙️ Mechanism of Action:
Halobetasol binds to glucocorticoid receptors, inhibiting inflammatory cytokines and mediators such as:
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Prostaglandins
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Interleukins (IL-1, IL-6)
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Tumor Necrosis Factor (TNF-α)
This leads to:
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Suppression of inflammation
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Reduction in erythema, edema, and pruritus
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Decrease in immune cell activity
💊 Dosage & Administration:
| Application | Details |
|---|---|
| Frequency | Once or twice daily |
| Amount | Thin layer over affected skin |
| Duration | Limit to <2 weeks unless advised |
| Max Weekly Dose | Should not exceed 50g/week |
| Pediatric Use | Not recommended in children <12 years |
| Application Site | Avoid face, groin, axillae unless specified |
⚠️ Precautions & Warnings:
| ⚠️ Caution With | 💡 Explanation |
|---|---|
| Long-term use | Risk of skin atrophy, tachyphylaxis, rebound flares |
| Occlusive dressings | Increase absorption → systemic effects |
| Children, elderly | Higher risk of systemic absorption |
| Face, eyelids, genitals | Higher sensitivity & risk of side effects |
| Infections | Do not use in fungal, bacterial, viral infections unless combined therapy is indicated |
🧪 Potential Side Effects:
| Local | Systemic (rare, prolonged use) |
|---|---|
| Burning, itching, irritation | Hypothalamic-pituitary-adrenal (HPA) suppression |
| Skin thinning (atrophy) | Cushingoid symptoms (moon face, weight gain) |
| Stretch marks (striae) | Hyperglycemia, hypertension |
| Acneiform eruptions | Adrenal insufficiency on withdrawal |
| Perioral dermatitis | Growth suppression in children |
| Hypopigmentation |
🧾 Storage Instructions:
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Store below 25°C
-
Keep away from direct sunlight and moisture
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Keep out of children’s reach
-
Do not freeze
🔁 Alternate Brands of Halobetasol Propionate 0.05%:
| Brand Name | Manufacturer | Form | Remarks |
|---|---|---|---|
| Halovate | Glenmark | Cream | Trusted, widely prescribed |
| Ultravate | Sun Pharma | Cream/Oint | Alternative formulation |
| Powercort | Hegde & Hegde | Cream | Cost-effective |
| Halox-S | Systopic | Lotion | For scalp or hairy areas |
| Halobate | Zydus Cadila | Cream | Equivalent generic |
| Halopik | Intas Pharma | Cream | Affordable & effective |
⚠️ Some brands may also come in combination with antibiotics (Fusidic acid) or antifungals, which are intended for infected or mixed dermatoses.
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Halovate Cream is a super-potent corticosteroid, ideal for short-term management of severe inflammatory skin conditions.
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Should be used only under strict medical supervision due to high risk of side effects.
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Not suitable for casual or cosmetic use.
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Prefer low- or mid-potency steroids (e.g., hydrocortisone, betamethasone) for sensitive areas or long-term use.
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